氨基酸糖苷类Amino acid glycosides.docx
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氨基酸糖苷类Amino acid glycosides.docx
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氨基酸糖苷类Aminoacidglycosides
氨基酸糖苷类(Aminoacidglycosides)
[testquestions]
(1)multiple-choicequestions
TypeAproblem
1.,aboutaminoglycosideantibiotics,thecorrectstatementisthat
A.isacidic
B.chemicalpropertyisunstable
C.oralabsorption
D.ismainlyexcretedthroughthekidneys
E.belongstoalkaloids
2.drugsthatarenotaminoglycosideantibioticsare:
A.Neomycin
B.tobramycin
C.sisomicin
Netilmicin,D.
JosE.
3..Whatkindofbacteriaareineffectiveforaminoglycosideantibiotics?
A.anaerobicbacteria
PseudomonasaeruginosaB.
C.tuberclebacillus
D.Gram-negativebacteria
E.Gram-positivebacteria
4.aminoglycosideantibioticsaremainlydistributedin:
A.CSF
B.serosacavity
C.plasma
D.intracellularfluid
E.extracellularfluid
Theincidenceofanaphylacticshockin5.aminoglycosidesisthehighest:
A.gentamicin
B.streptomycin
C.Neomycin
D.kanamycin
E.tobramycin
Thehighestincidenceofvestibularfunctiondamagein6.aminoglycosidesis:
A.kanamycin
B.streptomycin
C.Neomycin
D.sisomicin
E.tobramycin
Thehighestincidenceofcochlearnerveinjuryin7.aminoglycosidesis:
A.kanamycin
B.streptomycin
C.Neomycin
D.sisomicin
E.tobramycin
8.streptomycinandfurosemidecombinationwillcause:
A.nephrotoxicityincreased
B.ototoxicityincrease
C.increasedantimicrobialactivity
D.increaseddiuresis
E.hasnoobviouseffect
9.plagueandrabbitfeverarethefirsttreatmentoptions:
A.streptomycin
B.gentamicin
Amikacin,C.
D.tobramycin
E.Neomycin
10.drugsthatareineffectiveagainstPseudomonasaeruginosaare:
A.gentamicin
B.tobramycin
C.Amikacin
D.sisomicin
E.kanamycin
11.drugsthatareeffectiveintreatingtuberculosisare:
A.gentamicin
B.Amikacin
C.kanamycin
D.tobramycin
Netilmicin,E.
12.,thedescriptionofgentamiciniscorrect:
A.wasineffectiveagainstPseudomonasaeruginosa
B.shouldnotbeusedincombinationwithampicillinandbenzylpenicillin
C.theconcentrationoftheliquidintheurineislow
AntimicrobialspectrumofD.isthemostwidelyusedinaminoglycosides
E.canbeusedinthetreatmentoftuberculosis
13.,Amikacin'sroleischaracterizedby:
AntimicrobialspectrumofA.isthemostwidelyusedinaminoglycosides
B.issusceptibletodrugresistance
C.wasineffectiveagainstPseudomonasaeruginosa
D.ishighlytoxic
E.canbeusedinthetreatmentoftuberculosis
14.bacterialresistancetoaminoglycosidesisduetoproduction:
A.hydrolase
B.peptidase
C.b-lactamase
D.inactivationenzyme
E.synthetase
15.thefollowingdescriptioniswrongtotobramycin:
A.ismadebydeoxygenationofkanamycinB
B.hasastrongeffectonPseudomonasaeruginosa
C.canbeusedforthetreatmentoftuberculosis
D.hasantimicrobialactivityevenwhenresistantstrainsofPseudomonasaeruginosaareproduced
E.canbeusedfortheinfectionofPseudomonasaeruginosa
16.neomycinforclinicaluse:
A.isusedforPseudomonasaeruginosainfection
B.isusedforintestinalinfectionorabdominalpreoperativedisinfection
TreatmentofurinarysysteminfectionwithC.
TreatmentoflobarpneumoniawithD.
E.treatmentoftuberculosis
Themechanismofactionof17.aminoglycosideantibioticsis:
A.preventsbacterialcellwallsynthesis
B.inhibitsdihydrofolatesynthetase
C.increasesthepermeabilityofthecellmembrane
D.inhibitsDNAhelicase
E.blocksthesynthesisofbacterialproteins
18.andthecombinationispronetorespiratoryparalysiscurare:
A.penicillin
B.streptomycin
C.erythromycin
D.sulfadiazine
E.tetracycline
TypeBproblem
A.streptomycin,B.neomycin,C.spectinomycin,D.,Amikacin,E.,kanamycin
19.drugsthatareineffectiveagainstPseudomonasaeruginosaare
20.、thecommonlyusedmedicinefortuberculosisis
21.becauseofitshightoxicity,itisforbiddentotakeintravenousinjection
22.clinicalonlyforthetreatmentofuncomplicatedgonorrheais
A.B.AmikacinC.D.streptomycingentamicinkanamycintobramycinE.
23.thefirstremedyforplagueis
24.,thetreatmentofgram-negativebacilliinfection,suchassepsis,isthepreferreddrug
Amongthe25.aminoglycosideantibiotics,themostwidelyusedareantibiotics
26.ofthemostpowerfuldrugsagainstPseudomonasaeruginosaare
TypeXproblem
27.,bacterialresistancetoaminoglycosidesisthecauseofdrugresistance:
A.
Hydrolyticenzymes
B.producesinactiveenzymes
AlterationsincellwallpermeabilityofC.bacteria
D.bacterialackautolysisenzymes
AbnormalitiesinintracellulartransportfunctionofE.bacteria
28.aminoglycosideantibioticsaffectthesynthesisofproteins,including
TheformationofA.inhibitsribosomal70ssubunitinitiationcomplex
B.damagesbacterialcellmembranes
C.blocksthereleaseofpeptidechains
D.bindstothetargetproteinonthenucleocapsid30Ssubunit
E.blocksthebindingofthedrugtothe50Ssubunitofthebacterialnucleoprotein
29.thestatementaboutaminoglycosideantibioticsiscorrect:
A.oralabsorptionless
B.ismainlydistributedintheextracellularfluid
C.isdifficulttopenetratetheblood-brainbarrier
D.hashighconcentrationsofdrugsinurine
E.enterstheinnerear,andtheconcentrationoflymphisproportionaltothedosage
30.,theadverseeffectsofaminoglycosideantibioticsarecorrect:
A.GastrointestinalResponse
B.ototoxicity
C.allergicreaction
D.nephrotoxicity
E.neuromuscularparalysis
31.aminoglycosideantibioticototoxicityappearednarrativeiscorrect:
A.cancausedamagetothecochlea,nerveandvestibule
B.hasthehighestprevalenceofstreptomycin
ThereasonforC.istheaccumulationofdrugsinthelymphfluidoutsidetheinnerear
D.withvancomycin,furosemidecombinationcanaggravatetheototoxicity
E.firstaffectsthelow-frequencypart,andthenaffectshigh-frequencyhearing
32.drugsthatcauseanaphylacticshockare:
A.erythromycin
B.penicillinG
C.gentamicin
D.streptomycin
E.kanamycin
33.clinicalindicationsforstreptomycinareavailable:
A.isthefirstchoiceforplagueandrabbitfever
B.isusedincombinationwithotherdrugsforthetreatmentoftuberculosis
C.treatmentforbrucellosisandinfectiveendocarditis
D.cantreatotitismedia
E.isusedforsystemicinfectiousdiseases
34.effectivedrugsforPseudomonasaeruginosaare:
A.gentamicin
B.kanamycin
C.Amikacin
D.sisomicin
Netilmicin,E.
35.aminoglycosideantibioticsthatareavailableforthetreatmentoftuberculosisare:
A.streptomycin
B.gentamicin
C.Amikacin
D.kanamycin
E.tobramycin
36.theeffectofgentamiciniscorrect:
A.orallyforintestinalsterilization
B.hasawidespectrumofantimicrobialactivityandhasabactericidaleffectagainstgramnegativebacteriaandpositivebacteria
C.iseffectiveagainstPseudomonasaeruginosa
D.canbeusedinthetreatmentoftuberculosis
E.serioussepsiscausedbygram-negativebacilliinfection,pneumoniaandsoon,canbeusedasthefirstchoice
37.drugswithnephrotoxicityareavailable:
A.vancomycin
B.polymyxinB
C.streptomycin
D.tobramycin
E.Neomycin
(two)fillintheblanks
1.aminoglycosideantibiotics,including,,andsoon,haveacommonmechanismofaction.
2.aminoglycosideantibioticsweretakenorallyonlyfortreatment.Thedistributionisdifficulttopenetrate.
3.aminoglycosideantibioticsbelongtobactericide,theyhavestrongeffectonbacteria,andenhancetheantibacterialeffectinenvironment.
Theadversereactionsof4.aminoglycosideantibioticsare,,and.
5.aminoglycosideantibioticsinducedototoxicity,includingtwoaspects,theformerisshowed,andthelatter,.
6.thereasonforbacterialresistancetoaminoglycosidesisthegenerationofdrugsthatalterthestructureofthedrugandloseantimicrobialactivity,andfurthermore,changeisthecauseofdrugresistance.
7.streptomycinhasapowerfuleffectonbacteria,andisthefirstchoiceforclinicaltreatment.
8.streptomycinforthetreatmentofurinarytractinfection,toimprovetheefficacyofurine.
9.streptomycinbecauseitcanappearnervemuscleblockaction,soitisnotsuitableandapplicable.
10.gentamicinisthefirstchoiceforthetreatmentofseverebacterialinfectionssuchasosteomyelitisandpneumonia.
11.kanamycininducedototoxicity,andsomeotherdrugsandshouldnotbeused.
Amongthe12.aminoglycosideantibiotics,themostwidelyusedareantibiotics.TobramycinonPseudomonasaeruginosathangentamicin.
Anaphylacticshockoccursin13.aminoglycosideantibioticsandisavailableforsalvage.
14.gentamicinandthiskindofmedicine,andsoon,canincreasenephrotoxicity;
And,and,andthecombinationcanincreasetheototoxicity.
Intravenousinjectionof15.aminoglycosideinducedneuromuscularparalysis.
(three)nouninterpretation
1.whatisaminoglycosideantibiotics?
Whatarethecommonlyuseddrugs?
2.ototoxicity
3.whatispassivationenzyme?
Whatfunctiondoesithave?
(four)questionsandanswers
1..Thepharmacologicalbasisofenhancingtheantibacterialactionofaminoglycosideantibioticsandb-lactams.
2.todiscusstheinvivoprocessandsideeffectsofaminoglycosideantibiotics.
3.brieflydescribetheantimicrobialspectrumandadversereactionsofstreptomycinanditspreventionandtreatmentmeasures
4.brieflydescribetheantibacterialspectrumandclinicalapplicationofgentamicin.
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