美国药典USP中规定的色谱柱类型.docx
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美国药典USP中规定的色谱柱类型.docx
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美国药典USP中规定的色谱柱类型
美国药典(USP)中规定的色谱柱类型
ChromatographicReagents
Thefollowinglistofpackings(L),phases(G),andsupports(S)isintendedtobeaconvenientreferenceforthechromatographer.[note—Particlesizesgiveninthislistingarethosegenerallyprovided.Whereother,usuallyfiner,sizesarerequired,theindividualmonographspecifiesthedesiredparticlesize.Withinanycategoryofpackingsorphaseslistedbelow,theremaybeawiderangeofcolumnsavailable.Whereitisnecessarytodefinemorespecificallythechromatographicconditions,theindividualmonographsoindicates.]
Changetoread:
Packings
L1—Octadecylsilanechemicallybondedtoporoussilicaorceramicmicro-particles,1.5to10µmindiameter,oramonolithicsilicarod.
L2—Octadecylsilanechemicallybondedtosilicagelofacontrolledsurfaceporositythathasbeenbondedtoasolidsphericalcore,30to50µmindiameter.
L3—Poroussilicaparticles,3USP31to10µmindiameter,oramonolithicsilicarod.USP31
L4—Silicagelofcontrolledsurfaceporositybondedtoasolidsphericalcore,30to50µmindiameter.
L5—Aluminaofcontrolledsurfaceporositybondedtoasolidsphericalcore,30to50µmindiameter.
L6—Strongcation-exchangepacking–sulfonatedfluorocarbonpolymercoatedonasolidsphericalcore,30to50µmindiameter.
L7—Octylsilanechemicallybondedtototallyporoussilicaparticles,1.5to10µmindiameter,oramonolithicsilicarod.USP31
L8—Anessentiallymonomolecularlayerofaminopropylsilanechemicallybondedtototallyporoussilicagelsupport,3to10µmindiameter.
L9—Irregularorspherical,totallyporoussilicagelhavingachemicallybonded,stronglyacidiccation-exchangecoating,3to10µmindiameter.
L10—Nitrilegroupschemicallybondedtoporoussilicaparticles,3to10µmindiameter.
L11—Phenylgroupschemicallybondedtoporoussilicaparticles,1.5to10µmindiameter.
L12—Astronganion-exchangepackingmadebychemicallybondingaquaternaryaminetoasolidsilicasphericalcore,30to50µmindiameter.
L13—Trimethylsilanechemicallybondedtoporoussilicaparticles,3to10µmindiameter.
L14—Silicagelhavingachemicallybonded,stronglybasicquaternaryammoniumanion-exchangecoating,5to10µmindiameter.
L15—Hexylsilanechemicallybondedtototallyporoussilicaparticles,3to10µmindiameter.
L16—Dimethylsilanechemicallybondedtoporoussilicaparticles,5to10µmindiameter.
L17—Strongcation-exchangeresinconsistingofsulfonatedcross-linkedstyrene-divinylbenzenecopolymerinthehydrogenform,7to11µmindiameter.
L18—Aminoandcyanogroupschemicallybondedtoporoussilicaparticles,3to10µmindiameter.
L19—Strongcation-exchangeresinconsistingofsulfonatedcross-linkedstyrene-divinylbenzenecopolymerinthecalciumform,about9µmindiameter.
L20—Dihydroxypropanegroupschemicallybondedtoporoussilicaparticles,5to10µmindiameter.
L21—Arigid,sphericalstyrene-divinylbenzenecopolymer,5to10µmindiameter.
L22—Acation-exchangeresinmadeofporouspolystyrenegelwithsulfonicacidgroups,about10µminsize.
L23—Ananion-exchangeresinmadeofporouspolymethacrylateorpolyacrylategelwithquaternaryammoniumgroups,about10µminsize.
L24—Asemi-rigidhydrophilicgelconsistingofvinylpolymerswithnumeroushydroxylgroupsonthematrixsurface,32to63µmindiameter.
[note—AvailableasYMC-PackPVA-SILmanufacturedbyYMCCo.,Ltd.anddistributedbyWatersCorp.().]
L25—Packinghavingthecapacitytoseparatecompoundswithamolecularweightrangefrom100–5000(asdeterminedbypolyethyleneoxide),appliedtoneutral,anionic,andcationicwater-solublepolymers.Apolymethacrylateresinbase,cross-linkedwithpolyhydroxylatedether(surfacecontainedsomeresidualcarboxylfunctionalgroups)wasfoundsuitable.
L26—Butylsilanechemicallybondedtototallyporoussilicaparticles,3to10µmindiameter.
L27—Poroussilicaparticles,30to50µmindiameter.
L28—Amultifunctionalsupport,whichconsistsofahighpurity,100,sphericalsilicasubstratethathasbeenbondedwithanionicexchanger,aminefunctionalityinadditiontoaconventionalreversedphaseC8functionality.
L29—Gammaalumina,reverse-phase,lowcarbonpercentagebyweight,alumina-basedpolybutadienesphericalparticles,5µmindiameterwithaporevolumeof80.
L30—Ethylsilanechemicallybondedtototallyporoussilicaparticles,3to10µmindiameter.
L31—Ahydroxide-selective,stronganion-exchangeresin-quaternaryaminebondedonlatexparticlesattachedtoacoreof8.5-µmmacroporousparticleshavingaporesizeof2000andconsistingofethylvinylbenzenecross-linkedwith55%divinylbenzene.
L32—Achiralligand-exchangepacking–l-prolinecoppercomplexcovalentlybondedtoirregularlyshapedsilicaparticles,5to10µmindiameter.
L33—Packinghavingthecapacitytoseparatedextransbymolecularsizeoverarangeof4,000to500,000Da.Itisspherical,silica-based,andprocessedtoprovidepHstability.
[note—AvailableasTSKgelG4000SWXLfromTosohBiosep().]
L34—Strongcation-exchangeresinconsistingofsulfonatedcross-linkedstyrene-divinylbenzenecopolymerintheleadform,about9µmindiameter.
L35—Azirconium-stabilizedsphericalsilicapackingwithahydrophilic(diol-type)molecularmonolayerbondedphasehavingaporesizeof150.
L36—A3,5-dinitrobenzoylderivativeofl-phenylglycinecovalentlybondedto5-µmaminopropylsilica.
L37—Packinghavingthecapacitytoseparateproteinsbymolecularsizeoverarangeof2,000to40,000Da.Itisapolymethacrylategel.
L38—Amethacrylate-basedsize-exclusionpackingforwater-solublesamples.
L39—Ahydrophilicpolyhydroxymethacrylategeloftotallyporoussphericalresin.
L40—Cellulosetris-3,5-dimethylphenylcarbamatecoatedporoussilicaparticles,5to20µmindiameter.
L41—Immobilized1-acidglycoproteinonsphericalsilicaparticles,5µmindiameter.
L42—Octylsilaneandoctadecylsilanegroupschemicallybondedtoporoussilicaparticles,5µmindiameter.
L43—Pentafluorophenylgroupschemicallybondedtosilicaparticlesbyapropylspacer,5to10µmindiameter.
L44—Amultifunctionalsupport,whichconsistsofahighpurity,60,sphericalsilicasubstratethathasbeenbondedwithacationicexchanger,sulfonicacidfunctionalityinadditiontoaconventionalreversedphaseC8functionality.
L45—Betacyclodextrinbondedtoporoussilicaparticles,5to10µmindiameter.
L46—Polystyrene/divinylbenzenesubstrateagglomeratedwithquaternaryaminefunctionalizedlatexbeads,about10µmindiameter.
L47—High-capacityanion-exchangemicroporoussubstrate,fullyfunctionalizedwithtrimethlyaminegroups,8µmindiameter.
[note—AvailableasCarboPacMA1anddistributedbyDionexCorp.().]
L48—Sulfonated,cross-linkedpolystyrenewithanouterlayerofsubmicron,porous,anion-exchangemicrobeads,15µmindiameter.
L49—Areversed-phasepackingmadebycoatingathinlayerofpolybutadieneontosphericalporouszirconiaparticles,3to10µmindiameter.
[note—AvailableasZirchromPBD,manufacturedbyZirChromSeparations,Inc.,distributedbyAlltech,www.A.]
L50—Multifunctionresinwithreversed-phaseretentionandstronganion-exchangefunctionalities.Theresinconsistsofethylvinylbenzene,55%cross-linkedwithdivinylbenzenecopolymer,3to15µmindiameter,andasurfaceareanotlessthan350m2perg.Substrateiscoatedwithquaternaryammoniumfunctionalizedlatexparticlesconsistingofstyrenecross-linkedwithdivinylbenzene.
[note—AvailableasOmniPacPAX-500anddistributedbyDionexCorp.().]
L51—Amylosetris-3,5-dimethylphenylcarbamate-coated,porous,spherical,silicaparticles,5to10µmindiameter.
[note—AvailableasChiralpakADfromChiralTechnologies,Inc.,().]
L52—Astrongcation-exchangeresinmadeofporoussilicawithsulfopropylgroups,5to10µmindiameter.
[note—AvailableasTSKICSWCationfromTosohBiosep().]
L53—Weakcation-exchangeresinconsistingofethylvinylbenzene,55%cross-linkedwithdivinylbenzenecopolymer,3to15µmdiameter.Substrateissurfacegraftedwithcarboxylicacidand/orphosphoricacidfunctionalizedmonomers.Capacitynotlessthan500µEq/column.
[note—AvailableasIonPacCS14distributedbyDionexCorp.().]
L54—Asizeexclusionmediummadeofcovalentbondingofdextrantohighlycross-linkedporousagarosebeads,about13µmindiameter.
[note—AvailableasSuperdexPeptideHR10/30fromAmershamPharmaciaBiotech().]
L55—Astrongcation-exchangeresinmadeofporoussilicacoatedwithpolybutadiene–maleicacidcopolymer,about5µmindiameter.
[note—AvailableasIC-PakCM/DfromWatersCorp.().]
L56—Propylsilanechemicallybondedtototallyporoussilicaparticles,3to10µmindiameter.
[note—AvailableasZorbaxSB-C3fromAgilentTechnologies(
L57—Achiral-recognitionprotein,ovomucoid,chemicallybondedtosilicaparticles,about5µmindiameter,withaporesizeof120.
[note—AvailableasUltronES-OVMfromAgilentTechnologies(
L58—Strongcation-exchangeresinconsistingofsulfonatedcross-linkedstyrene-divinylbenzenecopolymerinthesodiumform,about6to30µm1S(USP31)indiameter.
[note—AvailableasAminexHPX-87NfromBio-RadLaboratori
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