DNA甲基化与结直肠癌早期诊断的研究现状.pdf
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DNA甲基化与结直肠癌早期诊断的研究现状.pdf
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2010203208DNA甲基化与结直肠癌早期诊断的研究现状刘琳1,许海南1(综述),方瑾2(审校)(1.中国医科大学七年制,沈阳110001;2.中国医科大学细胞生物教研室,沈阳110001)中图分类号:
R730.231文献标识码:
A文章编号:
100622084(2010)0921339203摘要:
结直肠癌中DNA甲基化异常已经被广泛地研究,特别是基因如APC的甲基化状态改变为结直肠腺瘤2癌的发展步骤之一已被广泛认同。
回顾和总结国内外对结直肠癌相关基因甲基化异常改变的研究及其进展发现,结直肠癌中除有基因突变外,同时都存在启动子CpG岛的异常甲基化。
现对CDKN2/p16、MGMT、p53、Maspin等基因甲基化与结直肠癌的关系及其在早期临床诊断中的应用进行综述。
关键词:
DNA甲基化;结直肠癌;早期诊断;基因ResearchStatusonDNAMethylationandColorectalCancerandItsEarlyDiagnosticValueLIULin1,XUHai2nan1,FANGJin2.(1.ClinicalMedicineofSeven2years,ChinaMedicalUniversity,Shenyang110001,China;2.CellBiologyDepartmentofChinaMedicalUniversity,Shenyang110001,China)Abstract:
DNAmethylationabnormalitiesincolorectalcancerhasbeenresearchedthoroughly,leadingtothewidelyacceptedthefactthatgenessuchasAPCbeingmethylizedisanindispensableprocessinorderforcolorectaladenomastobecomemalignant.Additionalstudiesfindthatotherthangenes,themethylationofpromoterCpGislandisalsopresentincolo2rectalcancer.Thearticlesumma2rizedcurrentresearchesonDNAmethylationstand,alongwiththegenessuchasCDKN2/p16,MGMT,p53andMaspinbeingmethylizedthatisrelatedtocolorectalcancer,aswellasitsearlyclinicaldiag2nosticvalue.Keywords:
DNAmethylation;Colorectalcancer;Earlydiagnosis;Gene结直肠癌是常见的消化道恶性肿瘤,占胃肠道肿瘤的第二位。
DNA甲基化在肿瘤中是一种普遍的分子改变,它与肿瘤的发生、发展都有着密切的关
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