SAQspart 31411421.docx
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SAQspart31411421
Self-AssessmentQuestionsForMedicalImmunology
---Part3(14级临床)
Chapter11~15
Ⅰ.MultipleChoiceQuestions
(Foreachquestion,choosetheONEBESTanswerorcompletion.)
Chapter11Antigenpresentingcellsandantigenpresentation
1.Whichofthefollowingisincorrectconcerningtheprocessingofanantigen,suchasabacterialprotein,intheacidcompartmentsofthecell?
A)ItresultsinproductionofpotentiallyimmunogenicpeptidesthatassociatewithMHC
classIImolecules.
B)Predominantlyexogenousantigensareprocessedbythispathway.
C)ItmayleadtoactivationofCD4+Tcells.
D)ItmayleadtotheactivationofCD8+Tcells.
E)BacteriallyderivedpeptidesdisplaceafragmentoftheinvariantchainfromtheMHCclassIIbindinggroove.
2.Theroleoftheantigen-presentingcellintheimmuneresponseisallofthefollowingexcept
A)thelimitedcatabolism(分解代谢)ofpolypeptideantigens.
B)toallowselectiveassociationofMHCgeneproductsandpeptides.
C)tosupplysecondsignalsrequiredtofullyactivateTcells.
D)topresentnon-selfpeptidesassociatedwithMHCclassIImoleculestoBcells.
E)topresentpeptide-MHCcomplexestoTcellswiththeappropriatereceptor.
3.Peptidefragmentsgeneratedinthecell'scytoplasmaretransportedintotheendoplasmicreticulumbywhichofthefollowing?
A)MHCclassImoleculesB)TAP-1andTAP-2
C)HLA-DMD)theproteasome
E)invariantchain
4.Aslideofmacrophageswasstainedbyimmunofluorescence(免疫荧光)usingamonoclonalantibodyfortheTAP1/TAP2complex.Whichofthefollowingintracellularcompartmentswouldexhibitpositivestainingwiththisantibody?
A)Cellsurface
B)Endoplasmicreticulum
C)Golgiapparatus
D)ThecellswouldnotbepositivebecausetheTAP1/TAP2complexisnotexpressed
inmacrophages.
5.Theinitialprocessingofendogenousproteinsintosmallpeptidesoccurs
A)Withintheendoplasmicreticulum
B)Withinphagolysosomes(吞噬溶酶体)
C)Attheexteriorfaceoftheplasmamembrane
D)Attheproteasomewithinthecytoplasm
E)AttheGolgiapparatus
6.APCsarefoundinlymphoidandothertissues.Thesecellspossessavarietyofnames,features,
andmarkers.ThecharacteristicthesecellsmusthavetoserveasAPCstoCD4Tcells
A)surfaceIgB)CR1
C)FcRD)MHCclassII
E)ICAM-1
7.AllofthefollowingareprofessionalAPCExcept
A)MastcellsB)Macrophages
C)BcellsD)Dendriticcells
8.Professionalantigen-presentingcells(APCs)include:
A)Tcells,BcellsandNKcells
B)eosinophils,mastcells,andbasophils
C)keratinocytes(角质形成细胞),fibroblasts(成纤维细胞),andendothelialcells
D)maturedendriticcells(DCs),macrophagesandBcells
9.PeptidesthatbindtoMHCclassImolecules
A)arederivedfromendocytosedexogenousmolecules
B)aresynthesizedinthecytoplasm
C)cannotrecognizedbyaspecificTcellreceptor
D)arealwaysofmicrobialorigin
E)areneverprocessedbytheimmunesystem
10.MHCclassIIproteinsdoNOTtakeuppeptidesintheroughendoplasmicreticulum(RER)because:
A)theRERcontainsnoclassIIbindingpeptides
B)classIIproteinsaredegradedintheRER
C)classIIproteinsarenottranslatedintheRER
D)classIIproteinsarecoexpressedwithaninvariantchain(Ii)thatblockspeptidebinding
11.MHCclassIIisloadedwithpeptidesin:
A)RERB)theendosomeC)theplasmamembraneD)theGolgi
12.Theproteasome:
A)presentsantigensB)degradesproteinsintopeptides
C)transportspeptidesintotheERD)bindstoMHCclassI
13.AviralvaccineagainstSARSvirusisbeingdevelopedusingproteinsfromtheviralparticle.OneoftheproteinsisolatedfromthevirushasloopA,helixB,betapleatedsheetC,andloopDinitsstructure.Oninfectionofacell,peptidesfromloopAproteinareexpressedonthesurfaceofthecells.WherewouldthepeptidebeingpresentedtoTcellspresentonthesurfacemostlikelylie?
A)BetweentheαchainandβchainoftheMHCcomplex
B)BetweentheloopsoftheαchainofMHCcomplex
C)Betweenloopsofβ2-microglobulinofMHCcomplex
D)IntheDregionoftheheavychainoftheimmunoglobulin
E)OntheκlightchainoftheIgGisotypeoftheimmunoglobulin
14.AvirallyinfectedcellpresentstheviralantigenonthesurfaceofthecellonMHCclassI
molecules.IfaspecificpharmaceuticalagentweretobedevelopedthatwouldaffecttheMHCclassIpeptidepresentationpathway,thedrugwouldmostlyaffect:
A)TAPcomplexB)HLA-DR
C)InvariantchainD)Endocytosis
E)BindingoftheαandβchainsoftheMHCcomplex
15.Theexecutivearmoftheadaptiveimmunesystem,thelymphocytes,CD4andCD8rely
heavilyontheprocessofantigenpresentationbyMHCclassIIandclassIrespectively.WhatprocessisrelatedtoclassIIpresentation?
A)MHCproteinproducedbyHLA-A
B)PresenceofMHCmoleculesonallnucleatedcellsandplatelets
C)EndogenouslysynthesizedorcytoplasmicpeptidesbindtoMHC
D)InvariantchainbindingtoMHCcomplex
E)β2-microglobulinbindingtoMHCcomplex
16.IntheclassIMHCpathwayofantigenpresentation,peptidesgeneratedinthecytosolare
translocatedintotheendoplasmicreticuluminwhichofthefollowingways?
A)ByATP-dependenttransportviaTAPB)Bypassive diffusion
C)Byreceptor-mediatedendocytosisD)Throughmembranepores
E)Viatheproteasome
17.Whichofthefollowingstatementsaboutmicrobialantigenpresentationiscorrect?
A)ClassIMHCmoleculesdisplaypeptidesderivedmainlyfromcytosolicmicrobialproteins
forrecognitionbyCD8+ Tcells
B)ClassIMHCmoleculesdisplaypeptidesderivedmainlyfromcytosolicmicrobialproteins
forrecognitionbyCD4+ Tcells
C)ClassIIMHCmoleculesdisplaypeptidesderivedmainlyfromcytosolicmicrobial
proteinsforrecognitionbyCD4+ Tcells
D)ClassIIMHCmoleculesdisplaypeptidesderivedmainlyfromextracellularmicrobial
proteinsforrecognitionbyCD8+ Tcells
E)ClassIIMHCmoleculesdisplaypeptidesderivedmainlyfromextracellularmicrobial
proteinsforrecognitionbyB cells
Chapter12TLymphocytes
1.ThebasicstructureofaTcellreceptorconsistsof
A)amembrane-boundorheterodimer(异二聚体).
B)acomplexofdisulfide-linkedheavyandlightchains.
C)covalentlylinkedCD3molecules.
D)peptide-MHCcomplexes.
E)solubleantigen-bindinghomodimer(同二聚体).
2.WhichofthefollowingmoleculesisexpressedbyamatureTcellthatfunctionsasahelperTcell?
A)CD4B)CD8C)GlyCAM-1D)IgAE)IgG
3.Tcellreceptors,whencoexpressedwithCD8molecules,arerestrictedtorecognizingandbindingpeptidefragmentsassociatedwith
A)CD3moleculesB)CD4molecules
C)MHCclassImoleculesD)MHCclassIImolecules
E)MHCclassIIImolecule
4.ThefunctionoftheCD4moleculeisto
A)promotethetransportofTCRfromtheroughendoplasmicreticulum(RER)tothemembrane
B)transmitthecellactivationsignalfromtheFcreceptor
C)stabilizetheunionofTcellsandMHCclassIImoleculesonAPCs
D)presentantigenicpeptidestoTcells
E)promotetheco-expressionofCD8onTcells
5.CD3is:
A)acomplexoftransmembraneproteinsinstrumentalinintracellularsignaling
B)amonomerictransmembraneproteinsinstrumentalinintracellularsignaling
C)thetransmembranesignalingdomainoftheTCR
D)thecytoplasmicdomainoftheTCR
6.CD4
A)bindsdirectlytopeptideantigen.
B)bindstoaninvariantportionofMHCclassImolecules.
C)bindstoaninvariantportionofMHCclassIImolecules.
D)bindstoCD8ontheTcellsurface.
E)bindstothepeptide-bindingsiteofMHCclassII.
7.Whichofthefollowingstatementsisincorrectconcerningantigen-specificreceptorsonbothBandTcells?
A)Theyareclonallydistributedtransmembranemolecules.
B)Theyhaveextensivecytoplasmicdomainsthatinteractwithintracellularmolecules.
C)Theyconsistofpolypeptideswithvariableandconstantregions.
D)Theyareassociatedwithsignaltransductionmoleculesatthecellsurface.
E)Theycaninteractwithpeptidesderivedfromnonselfantigens.
8.CD40ligand(CD40L)isexpressedbywhichofthefollowing?
A)BcellsB)dendriticcells
C)restingTcellsD)activatedTcells
E)allleukocytes
9.WhenantigenbindstotheTcellreceptor,whichofthefollowingisinvolvedinsignaltransduction?
A)CD3B)CD21
C)LFA-1(CD11a/CD18)D)Ig/Ig(CD79a/CD79b)
10.WhichofthefollowingsurfacereceptorsdoesNOTtransduceasignalintotheTcell?
A)CD3B)andchainsoftheTCR
C)CD4D)CD8
E)CD28
11.ThemoleculethatexistsonthesurfaceofalltheTcellsis:
A)TCRB)BCRC)CD40LD)CD4E)CD8
12.WhichofthefollowingisnottrueaboutTCR
A)ThefunctionofTCRistorecognizespecificantigen.
B)TCRcandirectlyrecognizeepitopeonthesurfaceofproteinantigen.
C)TCRcanonlyrecognizeantigenpeptide-MHCmoleculecomplexonthesurfaceofAPCortargetcell.
D)TCRhasdoublespecificitywhenitrecognizesantigenpeptide-MHCmoleculecomplex.
E)TCRhasMHCself-restrictionwhenitrecognizesantigen.
13.TheTCRbinds:
A)peptideonlyB)MHConlyC)peptide-MHCD)cytokines
14.WhichoffollowingmoleculecontainITAMinitscytoplasmicsegment?
A)TCRB)BCRC)CD3D)CD4E)CTLA-4
15.TheligandofCD2moleculeis:
A)CD40B)CD28C)CD58D)CD4E)CD21
16.__________isonlyexpressedonactivatedTcellsbutnotonrestingTcells.
A)CD28B)TCRC)CD3D)CD4E)CTLA-4
17.TcellentryintothethymusisaccompaniedbytheexpressionofCD4andCD8.BythetimeTcellsmatureandexitthethymus,eachTcell
A)expresseshighlevelsofbothCD4andCD8
B)beginstoexpresssurfaceimmunoglobulin
C)nolongerexpressesTcellreceptors
D)expressesonlyCD4orC
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