世界最杰出的生物医学论文.docx

世界最杰出的生物医学论文.docx

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世界最杰出的生物医学论文

世界最杰出的生物医学论文

千名生物学家（Facultyof1000Biology）和千名医学家（Facultyof1000Medicine）是英国BioMedCentral出版集团，所建立的两个医学生物学论文数据库。

它是由美国哈佛大学和英国剑桥大学等近5000多名世界顶级生物医学同行专家，所推荐和评选出的世界医学和生物学的最新发表的论文所组成。

论文依据创新性、新理论、新发现、新技术、科学价值和实际应用前景等原则，从世界上几千种重要的医学生物学杂志，成千上万篇论文中，实时进行筛选和评定，评选出F1000因子，并进行分级排序，分为杰出（Exceptional9分）、必读（MustRead6分）和推荐（Recommend3分）三个级别，并写有简短的评语。

再向医学生物学界进行推荐和发布，以提供世界上最重要、最优秀的生物医学论文信息和最新研究成果与发展趋势。

F1000只重视论文的实际科学价值和临床应用前景，不考虑期刊的状况和论文在何处发表，影响因子（IF）值也仅仅作为辅助参考指标。

被推荐出的论文不足SCI发表论文的千分之二，其中杰出的论文仅占所推荐论文的5%。

F1000还依据不同的科学领域，适时评选出最近和最受关注（Must-Viewed）的10篇最佳论文，称为“Top10”，并不断更新。

此外还邀请世界上最知名和权威的领域科学家，编写生物医学最近的进展、评论和综述，刊登在“F1000Reports上”。

F1000是一个新的医学生物学论文数据库，是一个新的生物医学论文评价工具，是一个新的医学论文评估的专家系统。

它不仅可以帮助我们来快速检索世界上最“杰出”、“必须阅读”和“值得推荐”的生物医学论文；还可以了解每篇发表论文的专家评价观点和意见，使我们可以节时、高效、全面认识和了解当今世界上生物医学最新研究成果和发展动向，引导和促进生物医学科学的发展。

研究论文能为F1000所收录和推荐，成为F1000“杰出”论文，代表着该论文的极高的科学水平和重要的科学价值。

目前我国每年被SCI收录的医学生物学论文已逾万篇，成为“论文大国”，但能为F1000收录为“杰出”的论文却寥寥。

以2009—2010年为例，在F1000收录和推荐出1017篇“杰出”论文中，中国只有11篇，其中还有4篇是台湾和香港的。

从2000—2010年F1000共评出近5000篇“杰出”论文，中国（包括台湾和香港）总共只有25有篇。

反应出我国现在医学生物学研究“跟”多“创”少，重“量”不重“质”；一般资料性的工作多，有创新性、有实际应用价值、有重要理论和应用前景的论文少的潜在而深刻的危机。

我们必须在原始创新和实际应用上再上一层楼！

我们要发表SCI论文，要发表高IF影响因子论文；我们更要多发表F1000“杰出”论文，发表创新性强，有重要理论价值和实际应用前景的科学论文，这才能成为真正的科技强国。

这里我们收集了2009－2010年心血管、肿瘤、细胞生物学、分子生物学、免疫学、神经科学等领域F1000的“杰出”论文供大家参考，更多的F1000论文，可在F1000Biology和F1000Medicine网站上搜索。

•  Biochemistry

•  Bioinformatics

•  Biotechnology

•  CancerBiology

•  CardiovascularBiology

•  CellBiology

•  ChemicalBiology

•  DevelopmentalBiology

•  Ecology

•  EvolutionaryBiology

•  GastrointestinalBiology

•  Genomics&Genetics

•  Immunology

•  Metabolic&EndocrineScience

•  Microbiology

•  MolecularBiology

•  MolecularMedicine

•  Neuroscience

•  Pharmacology&DrugDiscovery

•  Physiology

•  PlantBiology

•  RenalBiology

•  RespiratoryBiology

•  StructuralBiology

•  Anesthesiology&PainManagement

•  CardiovascularDisorders

•  CriticalCare&EmergencyMedicine

•  Dermatology

•  Diabetes&Endocrinology

•  Gastroenterology&Hepatology

•  Hematology

•  InfectiousDiseases

•  Nephrology

•  NeurologicalDisorders

•  Oncology

•  Otolaryngology

•  Psychiatry

•  PublicHealth&Epidemiology

•  ResearchMethodology

•  RespiratoryDisorders

•  Rheumatology&ClinicalImmunology

•  Urology

•  Women'sHealth

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F1000Report

cell-Amoverandashaker'-53BP1allowsDNAdoublestrandbreaksachancetodanceandunite

cell-Avirtualcycle-theoryandexperimentconvergeontheexitfrommitosis

cell-AberrantmRNAtranscriptsandnonsense-mediateddecay

cell-Autophagyofintracellularmicrobesandmitochondria-twosidesofthesamecoin

cell-Brd4engagementfromchromatintargetingtotranscriptionalregulation-selectivecontactwithacetylatedhistoneH3andH4

cell-Conformationalchangesinreceptortyrosinekinasesignaling-anErbBgardenofdelights

cell-Destroytocreate-E3ubiquitinligasesinneurogenesis

cell-Doingcellbiologyinembryos-regulatedmembranetrafficanditsimplicationsforcadherinbiology

cell-Epigeneticregulationofantigenreceptorgenerearrangement

cell-G-protein-coupledreceptorstructure

cell-Inducedpluripotentstem（iPS）cells-anup-to-the-minutereview

cell-InhibitorofApoptosis（IAP）proteinsasdrugtargetsforthetreatmentofcancer

cell-Intracellulartraffickingandsignalingindevelopment

cell-LOVconquers（sm）AllGTPases

cell-Membranedeformationandseparation

cell-Microtubulemotors-movingforwardonmanyfronts

cell-Mitochondriaandapoptosis-aquicktakeonalongview

cell-novelfunctionsoftheexocystcomplexinpolarizedepitheliainanimals

cell-PARPinhibitorsinBRCA1-BRCA2germlinemutationcarrierswithovarianandbreastcancer

cell-Plk4-SAK-ZYG-1intheregulationofcentrioleduplication

cell-Putativefunctionsofcaspase-2

cell-Recentadvancesinpolyubiquitinchainrecognition

cell-RecentadvancesinunderstandingGolgibiogenesis

cell-Regulatoryrolesofthecadherinsuperfamily

cell-Roleofcaspasesandnon-caspaseproteasesincelldeath

cell-RolesofAD-cofilininactinpolymerizationandbeyond

cell-RolesofthesmallGTPasesRhoAandRac1incellbehavior

cell-Single-moleculedynamicsofnuclearmRNA

cell-Spindlecheckpointsilencing-ensuringrapidandconcertedanaphaseonset

cell-TelomericRNAsasanovelplayerintelomericintegrity

cell-Theroles,mechanisms,andcontroversiesofautophagyinmammalianbiology

cell-Transportvesicleuncoating-it'slaterthanyouthink

cell-Understandinglipidraftsandotherrelatedmembranedomains

cell-Vesiclecoatinganduncoating-controllingtheformationoflargeCOPII-coatedcarriers

cell-Whentranscriptionmeetsrecombination

ecology-Characterizingchangesinmarineecosystemservices

ecology-Climatechangeandbiodiversityconservation-impacts,adaptationstrategiesandfutureresearchdirections

ecology-Currentthemesandrecentadvancesinmodellingspeciesoccurrences

ecology-Eco-evolutionarydynamics-intertwiningecologicalandevolutionaryprocessesincontemporarytime

ecology-Evaluationofglobalchangeimpactsondiffusepollution

ecology-Evolutionaryimpactsoffishing

ecology-Extinctionrisksfromclimatechange-macroecologicalandhistoricalinsights

Ecology-Modellingecosystemservicesinterrestrialsystems

ecology-Theconsequencesofhuman-drivenoceanacidificationformarinelife

ecology-Towardunderstandingtheeffectoftoppredatorsonecosystems

genome-Adirectmeasurementofcrossingoverinhumanprophaseoocytes

genome-Advancesinthegeneticsofprimarytorsiondystonia

genome-Applicationsofhigh-throughputsequencingtochromatinstructureandfunctioninmammals

genome-BioinformaticdetectionofhorizontallytransferredDNAinbacterialgenomes

genome-CRISPR-Cas-anadaptiveimmunitysysteminprokaryotes

genome-Distinctdisordersaffectingthebrainsharecommongeneticorigins

genome-Emergingtechnologiesforthegenomicanalysisofcancer

genome-Geneticsofpulmonaryarterialhypertension-dothemolecularfindingshavetranslationalvalue-

genome-Hiddenribozymesineukaryoticgenomesequence

genome-howmedicalsequencingandnetworkbiologywillenablepersonalizedmedicine

genome-Insulators-linkinggenomearchitecturetogeneregulation

genome-Mappingchromatinconformation

genome-Pharmacogeneticsofosteoporosis

genome-PRDM9sticksitszincfingersintorecombinationhotspotsandbetweenspecies

genome-Predictionoffunctioninproteinsuperfamilies

genome-RecA-independentsingle-strandedDNAoligonucleotide-mediatedmutagenesis

genome-RecentadvancesinRNAsequenceanalysis

genome-Retrotransposonsandgermcells-reproduction,death,anddiversity

genome-Theapplicationofmassivelyparallelsequencingtechnologies

genome-Ubiquitousantisensetranscriptionineukaryotes-novelregulatorymechanismorbyproductofopportunistic-NApolymerase

genome-Whentranscriptionmeetsrecombination-alessonfromthehumanRECQproteincomplexes

imm-AntigenprocessingforMHCpresentationbyautophagy

imm-inf-AnovelmucosalRORt+NKp46+cellsubsetisasourceofinterleukin-22

imm-inf-Advancesinunderstandingtheinteractionbetweenthegutmicrobiotaandadaptivemucosalimmuneresponses

imm-inf-Alternativemacrophageactivationandtheregulationofmetabolism

imm-inf-Anupdateonpathobiologicrolesofanti-glycanantibodiesinGuillain-Barr茅syndrome

imm-inf-Bcell-targetedtherapiesinautoimmunity-rationaleandprogress

imm-inf-Bacterialsurfaceproteinsandvaccines

imm-inf-Doapicomplexanparasite-encodedproteinsactasbothligandsandreceptorsduringhostcellinvasion

imm-inf-DoapicomplexanparasiteshijackthehostcellmicroRNApathwayfortheirintracellulardevelopment

imm-inf-DualityintheTh17-Tregdevelopmentaldecision

imm-inf-Electrontransportchainsoflacticacidbacteria-walkingoncrutchesispartoftheirlifestyle

imm-inf-Geneticreprogrammingofhostcellsbybacterialpathogens

imm-inf-Gutcommensalflora-toleranceandhomeostasis

imm-inf-HIVvaccination-turningthespotlightoneffectormemoryTcellsasmucosalgatekeepers

imm-inf-HIV-1hostinteractions-integrationoflarge-scaledatasets

imm-inf-Latestadvancesininnateantiviraldefence

imm-inf-LessonsfromthefailureoftheadenovectorHIVvaccine

imm-inf-NewtemplatesforHIV-1antibody-basedvaccinedesign

imm-inf-Ocularimmuneprivilege

imm-inf-Recentinsightsintofattyacidacquisitionandmetabolisminmalarialparasites

imm-inf-RecentstrategiestoidentifybroadlyneutralizingantibodiesagainstinfluenzaAvirus

imm-inf-RegulationoftheIgEresponse

imm-inf-Thegardenofantimicrobialdelights

imm-inf-Theinflammasomeandalum-mediatedadjuvanticity

imm-inf-Theroleofmicrobialpolysaccharidesinhost-pathogeninteraction

imm-inf-Thymicegress-S1Pof1000

imm-inf-TwomechanismsthataccountformajorhistocompatibilitycomplexrestrictionofTcells

imm-inf-WhyisPseudomonasaeruginosaapathogen

imm-TheroleofIL-23intheimmunopathogenesisofpsoriasis

ns-AcurrentviewofAlzheimer'sdisease

ns-Anuncorrelatedstateforthecortex

ns-channelopathies-newantibody-mediateddisordersofthecentralnervoussystem

ns-ControlofSchwanncellmyelination

ns-Denovoprions

ns-Developmentofobjectrecognitioninhumans

ns-DysfunctionoftheCaV2.1calciumchannelincerebellarataxias

ns-E3ubiquitinligasesinneurogenesis

ns-mechanotransductionininner-earhaircells

ns-Multiplefunctionsofdopamineneurons

ns-Musicdrivesbrainplasticity

ns-Neuronalcalciumsensorproteins

ns-Recentadvancesinneuraldevelopment

ns-Seeingwiththemind'seye

ns-Settingtheabsolu