级临床医学七年制药理学期末考试题.docx
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级临床医学七年制药理学期末考试题.docx
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级临床医学七年制药理学期末考试题
山东大学医学院
(2007——2008学年第二学期)
2005级临床医学七年制
药理学期末考试试题(A卷)
FINALTERMExamNATIONofPharmacologyfor
7-YEARS-2005
题号
一
二
三
四
五
六
七
总分
统分人
得分
得分
统分人
一、名词解释:
(每题2分,共10分)
1.First-orderkinetics
扣分
2.Therapeuticindex
扣分
3.Placebo
扣分
4.Postantibioticeffect
扣分
5.Superinfection
扣分
得分
统分人
二、选择题(A型每题0.6分;X型每题1分,共40分)
TypeAchoicequestions(onlyoneansweriscorrect)
1.pA2iscalled
A.therapeuticindex
B.affinityindex
C.antagonistindex
D.dissociationconstant
E.eliminationrateconstant
2.AweakbasedrugwithpKa9,ifthemediuminwhichitisdissolvedhasapH7,whatwillberatiooftheconcentrationsofionizedtounionizedformsofthebase?
A.100:
1
B.1:
100
C.10:
1
D.1000:
1
E.1:
1
3.Whichofthefollowingisunlikelytobeassociatedwithoraldrugadministrationofanenteric-coateddosageform?
A.irritationtothegastricmucosawithnauseaandvomiting
B.destructionofthedrugbygastricacidordigestiveenzymes
C.unpleasanttasteofthedrug
D.formationofnonabsorbabledrug-foodcomplexes
E.variabilityinabsorptioncausedbyfluctuationsingastricemptyingtime
4.WhichofthefollowingstatementisNOTtrue?
A.uptake1referstoneuronaluptake
B.uptake2referstometabolismuptake
C.uptake1isthemainpathwayofNAtermination
D.uptake2mostlyhappensinvesicles
E.uptake1isakindofactivetransport
5.WhichofthefollowinganticholinesteraseagentsisdrugchoiceinthetreatmentofAlzheimer’sdisease?
A.neostigmine
B.Edrophoniumchloride
C.Rivastigmine
D.Physostigmine
E.Organophosphates
6.WhichofthefollowingisNOTtheindicationofscopolamine?
A.pre-anaesthesiamedication
B.preventionofmotionsickness
C.Alzheimer’sdisease
D.Parkinsondisease
E.traditionalmedicineanaesthesia
7.Whichofthefollowingmydriasisagentsbelongstoadrenoceptoragonists?
A.atropine
B.phenylephrine
C.cyclopentolate
D.tropicamide
E.eucatropine
8.Torelieveanxietysymptoms,weusuallyuse
A.phenobarbital
B.perphenazine
C.chlorpromazine
D.imipramine
E.benzodiazepines
9.Whichofthefollowingdrugsiscontraindicatedinthepatientswithepilepsy?
A.phenobarbital
B.imipramine
C.digoxin
D.chlorpromazine
E.aspirin
10.AllofthefollowingproduceasignificantdecreaseinperipheralresistanceEXCEPT
A.chronicadministrationofdiuretics
B.hydralazine
C.ACEinhibitors
D.β-Rblockers
E.Calciumchannelblockers
11.Allofthefollowingmeasurescanbeusedinthetreatmentofdigoxin-inducedarrhythmiaEXCEPT
A.stoppingdigoxinadministration
B.diureticagentssuchasfurosemideareusedtopromotetheexcretionofdigoxin
C.phenytoinadministration
D.atropineadministration
E.lidocaineadministration
12.Thereasonthatdigoxincanreducetheventricularrateofatrialfibrillationpatientis
A.Decreasingautomaticityofventricles
B.Decreasingautomaticityofatria
C.ReducingtheconductionofA-Vnode
D.improvingcardiacischemia
E.shorteningtheeffectiverefractoryperiodatria
13.Whichofthefollowingisthemostseriousmainsideeffectofstatinsandthiseffectwouldbeincreasedifastatinistakenwithciclosporin,gemfibrozilornicotinicacid?
A.Gastrointestinalproblems
B.Rhabdomyolysis
C.Elevatedbloodpressure
D.Migraineheadaches
E.palpitations
14.Theantihypertensivemechanismofdiureticsforlong-termuseis
A.increasingwaterandsodiumexcretionfromthekidneys.
B.decreasingsodiumconcentrationinvascularsmoothmusclecell
C.increasingtheactivityofrennin
D.decreasingtheactivityofrennin
E.decreasingthesecretionofaldosterone
15.Inwhichofthefollowingdrugsorthostatichypotensionoccursmostfrequentlyinfirstuse?
A.clonidine
B.nifedipine
C.propranolol
D.enalapril
E.prazosin
16.Whichofthefollowingstatementsaboutcatopriliswrong?
A.inhibitingACE
B.causingdrycough
C.Itiscontraindicatedtopregnantwoman
D.promotetheexcretionpotassium
E.increasebradykininconcentrationintheblood
17.Whichofthefollowingdrugsisnotsuitabletotreatthepatientwithanginapectorisaccompaniedwithasthma?
A.nifedipine
B.propranolol
C.nitroglycerin
D.verapamil
E.isosorbidedinitrate
18.Thedrugchoiceforventriculararrhythmiacausedbycardiacglycosidespoisoningis
A.propranolol
B.sodiumphenytoin
C.quinidine
D.amiodarone
E.procainamide
19.Whichofthefollowingmechanismbestaccountsforthedecreasingbloodsugareffectofglibenclamide?
A.stimulatingβ-cellinpancreaticislanddirectly,promoptingthereleaseofinsulin
B.inhibittheactivityofα-glycosidase
C.decreasingtheabsorptiongofglulose
D.increasethesensitivityofinsulintotargetorganism
E.directlyactivitinginsulin-receptors
20.Whichofthefollowingstatementsaboutthetreatmentofchronicheartfailureiswrong?
A.patientswithevidenceoffluidretentionshouldreceiveadiuretic.
B.treatmentwithanACEinhibitorandaβ-Rblockershouldbeinitiatedandmaintainedunlessspecificallycontraindicated.
C.digoxinmaybeaddedifneededtoreducesymptomsortoslowtheventricularresponseinpatientswithrapidatrialfibrillation.
D.patientswithsevereheartfailureshouldalsoreceiveaβ-Rblocker
E.spironolactonemayreducemortalityinpatientswithsevereheartfailure
21.A76-year-oldmalewithCHFandhearinglossisgivenadiureticaspartofaregimenthatincludesdigoxinandanACEinhibitor.Inthecourseoftreatment,hedevelopsanAVconductiondefectandisfoundtobehypomagnesemic.Shealsohasworseninghearingloss,whichisreversedwhenthedrugstopped.Whichofthefollowingdiureticsdidsheused?
A.furosemide
B.hydrochlorothiazide
C.spironolactone
D.amiloride
E.mannitol
22.A70-year-oldfemaleistreatedwithsublingualnitroglycerinforheroccasionalboutsofangina.Whichofthefollowingisinvolvedintheactionofnitroglycerin?
A.α-adrenergicactivity
B.phosphodiesteraseactivity
C.phosphorylationoflightchainsofmyosin
D.norepinephrinerelease
E.cGMPincreased
23.A56-year-oldfemalehasrecentlydevelopedessentialhypertension,forwhichsheisreceivingchlorothiazidetolowerherbloodpressure.Whichofthefollowingionswouldnotincreasingconcentrationinherurine?
A.K+
B.Cl-
C.Ca2+
D.Na+
E.Mg2+
24.A58-year-oldpatientwithahistoryofhypertensionandcongestiveheartfailureadministratingsomedrugs,nowhecomplainsofnausea,blurredvisionandbradycardia,intoxicationofglycosideissuspected,thendigoxinisstopped,whichofthefollowingdrugsalsomustbestopped?
A.nifedipine
B.diazoxide
C.hydrochlorothiazide
D.prazosin
E.clonidine
25.Whichofthefollowingdiseasecanbetreatedwithlargedoseofiodium?
A.cretinism
B.solidedema
C.endemicgoiter
D.thyroidcrisis
E.mildthyroidism
26.Theappropriatetargetinthenephronoffurosemideis
A.Na+/K+/2Cl-cotransporteroftheluminalmembraneintheascendinglimbofHenle’sloop
B.Na+/2Cl-cotransporteroftheluminalmembraneinthedistaltubule
C.competeswithaldosteroneforintracellularcytoplasmicreceptorsites
D.Na+/H+exchangeroftheluminalmembraneincollectingduct
E.carbonicanhydraseofproximaltubule
27.Beingantagonizing5-HT3receptor,thedrugwithsignificanteffectagainstvomitingis
A.cimetidine
B.promethazine
C.ondansetron
D.ranitidine
E.nizatidine
28.VitKisasubstancetopreventorreducebleedingcausedby
A.heparin
B.aspirin
C.urokinase
D.streptokinase
E.dicoumarin
29.Whichofthefollowingmechanismsbestaccountsfortheanti-thyroideffectofmethylthiouracil?
A.inhibitingperoxidaseanddecreasingthethyroxinsynthesis
B.inhibitingthethyroidreleasing
C.inhibitingtheabsorptionofiodine
D.interferingwiththeutilizationofiodine
E.decomposingthethyroxin
30.A60-year-olddiabeticmaleistreatedwithpioglitazone.Whatisthemechanismofpioglitazone?
A.increasedreleaseofendogenousinsulin
B.decreasedplasmaglucagonlevels
C.increasedhepaticgluconeogenesis
D.increasedtargettissuesensitivitytoinsulin
E.decreasedintestinalabsorptionofglucose
31.Whichofthefollowingisthemostimportantapproachinpreventingpepticulcersfromrecurrence?
A.coatingtheulcercrater
B.eradicatinginfectionwithH.Pylori
C.inhibitingsecretionofgastricacidattheprotonpump
D.blockingreceptoractivationofgastricacidsecretion
E.neutralizingsecretedgastricacid
32.WhichofthefollowingstatementsaboutinsulinisNOTtrue?
A.Itcancausehyperglycemicreaction
B.Itcan’tbeadministratedorally
C.Itsmechanismofactionisthroughintracellularreceptorpathway
D.ItcanbeusedinIDDMandNIDDM
E.Itcancauseanaphylacticreaction
33.AllofthefollowingareindicationsofglucocorticoidsEXCEPT
A.rheumaticarthritis
B.bronchialasthma
C.pepticulcer
D.endotoxicshock
E.childhoodacuteleukemia
34.Whichofthefollowingstatementsaboutheparinistrue?
A.mildanticoagulativeeffect
B.slowonsetofeffect
C.noanticoagulativeeffectinvitro
D.possessinganticoagulativeeffectinvitro
E.Itcanbeadministratedorally
35.Theantiasthmaticeffectofsalbutamolisattributedto
A.stimulationofβ2receptor
B.blockadeofM-receptor
C.activationofguanylatecyclase
D.increaseofintracellularcGMP
E.inhibitionofphosphodiesterase
36.Whichofthefollowingtherapiesisthebestforapatientwithstatusasthmaticus?
A.aminophyllinep.o.
B.hydrocortisonei.v.
C.inhalingsodiumcromoglycate
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- 临床医学 七年 制药 理学 期末 考试题