大陆团来访学者演讲题目及摘要.docx
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大陆团来访学者演讲题目及摘要.docx
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大陆团来访学者演讲题目及摘要
大陸團來訪學者演講題目及摘要
郝柏林
中國科學院理論物理研究所研究員
E-mail:
hao@
演講題目:
One-dimensionalhistogramsofrandomizedgenomicsequences---asurpriseanditsexplanation
摘要:
FromourjointworkdoneinTaiwanin1997-1998withH.C.Leeweknowthatthe1DhistogramsofK-stringsinprokaryotecompletegenomesaremuchbiasedtowardslowcountswithalongtailofhighcopy-numberrepeatsandtheirrandomizedcounterpartsshowabell-shapeddistributioncenteredaroundtheaveragecount.Tooursurprise,aninspectionofmoreavailablegenomesrevealsrichstructuresinanumberofrandomizedsequences,fromdiscretetooverlappingpeakswithKincreasing.Itturnsoutthatthisphenomenonismainlycausedbythesignificantdeviationofg+ccontentfromthatofa+t.Wehopethisstudymayeventuallyleadtoafinerwayofcharacterizingthenucleotidecontentofgenomicsequencesthanusingg+ccontentalone.ThistalkwillserveasanintroductiontothemoremathematicalexplanationbyH.M.Xiebyshowingmanycolorfulpictures.
歐陽鐘燦
中國科學院理論物理所研究員
E-mail:
oy@
演講題目:
TheelastictheoryofsinglemoleculeDNA
摘要:
InthistalkwegiveasimplereviewontheexperimentsontheelasticdeformationofsinglemoelculeDNAandintroduceaelasticmodelwepresentedin1999toexplaintheexperimetal result
王鵬業
中國科學院理論物理研究所教授
E-mail:
pywang@
http:
//
演講題目:
Controlofspatiotemporaldynamicsinacardiacmodel
摘要:
Atraveling-waveperturbationmethodtocontrolthespatiotemporaldynamicsinanexcitablecardiacmodelisproposed.Itisnumericallydemonstratedthatthemethodcansuccessfullysuppressthewaveinstability(alternansinactionpotentialduration)intheone-dimensionalcaseandconvertspiralwavesandturbulentstatestothenormaltravelingwavestatesinthetwo-dimensionalcase
史華林
中國科學院理論物理研究所副研究員
E-mail:
shihl@
演講題目:
CooperativeEffectsontheKineticsofATPHydrolysisinCollectiveMolecularMotors
摘要:
Generally,molecularmotorsareATPase.Thereactionkineticsisstillanopenquestion.Inanrecentsinglemolecularexperimentperformedonkinesin(aprocessivemotor),thekineticsofATPhydrolysishavebeenstudiedundercontrolledexternalloads.ItseemsthatthekineticsofATPhydrolysisstillcanbedescribedbytheMichaelis-Mentenmechanism,whichintroducedin1913todescribetheprocessofenzymaticcatalysis.ButtheMichaelisconstantisload-dependent.Thisexperimentalresulthasbeenexplainedwellwithatwo-stateratchetmodel.Wefocusoncollectivemolecularmotors.Withintheframeworkofatwo-stateratchetmodel,thecooperativeeffectsonthekineticsofATPhydrolysisforcollectivemolecularmotorshavebeenstudiedindetail.WecalculatethedependenceoftherateofATPconsumptionontheappliedloadasafunctionofATPconcentration.Newfeaturesdifferentfromsinglemolecularmotorhavebeendiscovered.Weanalysetwotypicaloscillationsofcollectivemolecularmotorsalongfilamentsindetail.Therelationbetweenoscillatorycharacteristics,suchasfrequencyandamplitude,aswellasthedutyratewithATPconcentrationhavebeendiscussed.
肖奕
華中科技大學物理系教授
E-mail:
yxiao@
演講題目:
Quasi-periodicityAnalysisofAluRepeats
摘要:
ThegenomeofeukaryotesisknowntocontainvarioustypesofrepetitiveDNA.ThefunctionofrepetitiveDNAisunknown.AtypicalAluelementiscomposedoftwonearlyidenticalhalves(about130basepair)joinedbyamiddleA-richregionalongwitha3'PolyA(Adenine)tail.SomeanalysisgaverisetotheconceptthatinterspersedrepetitivesequencesareselfishDNAwithnofunctionorselectiveadvantagetotheorganism[1],whileothersarguedagainstitandpresentedthattheinterspersedrepetitivesequencesarerelatedtoregulatorynetworks,allowingthecoordinateexpressionofmultiple,unlinkedgene[2].
WeanalyzeAluelementsbyusingquasi-periodicitymethodandthepurposeistofindoutwhetherthereexistsspecialcodingpatterninAluelement.ThesequencesofAluelementsusedcanbeobtainedinEMBLwebsite.ThetotalnumberoftheAluelementsare128.
Quasi-periodicitycanbeusedtofindthesizeofthewordofwhichasequenceconsists.Toshowthis,wecalculatedthequasi-periodicityofhumanexonsandweareimmediatelyimpressedbythesignificantpeakatquasi-period3whichisclearlyinducedbythattheexonsarewritteninthree-letterwords,i.e.,geneticcodes.
ToseeifAluelementsalsohavecertaincodingpattern,wecalculatedthequasi-periodicityof128Aluelements.Itissurprisedthatwedoseeasignificantpeakatquasi-period8.Amongthe128Aluelements,40sequenceshaveexactquasi-periodicityof8.Ifweaddthenumberofsequenceswithquasi-periodicityof7and9,thereare80sequenceswhichis80%ofthetotalsequences.
Thisresultagreeswithwha
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