letter to editor 回复编辑的信SCI.docx
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letter to editor 回复编辑的信SCI.docx
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lettertoeditor回复编辑的信SCI
DearDr.XXX,
Thankyouforarrangingatimelyreviewforourmanuscript.WearepleasedtoknowthatourstudyisofgeneralinterestforthereadersofNUTRITION.Wehavecarefullyevaluatedthereviewers’criticalcommentsandthoughtfulsuggestions,respondedtothesesuggestionspoint-by-point,andrevisedthemanuscriptaccordingly.Allchangesmadetothetextareinredsothattheymaybeeasilyidentified.Withregardtothereviewers’commentsandsuggestions,wewishtoreplyasfollows:
Enclosures:
(1)Correspondencestoyourreviewers;
(2)Onecopyoftherevisedmanuscript;
(3)Afloppydiskcontainingtherevisedmanuscript.
(4)Copyrightassignment
Toreviewer #1
1.TheauthorshouldaddafewreviewarticlesonghrelinforreadersintheIntroduction.
Weaddedtworeviewsinourrevisedmanuscript.
2.Theincreaseinghrelinlevelsdonotnecessaryindicatethatweightlossindiseaseiswellcompensated(IntroductionandDiscussion).Thismaybeinterpretedtobeinsufficienttorecovertothepreviousbodyweight.
Thereispossibilitythattheincreaseinghrelinlevelsmayresultfromtheinsufficienttorecovertothepreviousbodyweight,butitismorelikelythattheincreaseinghrelinlevelindicatethatweightlossindiseaseiswellcompensated.Shimizuetal1reportedthatbaselineplasmaghrelinlevelwassignificantlyhigherincachecticpatientswithlungcancerthaninnoncachecticpatientsandcontrolsubjects.Asweightlossisachronicprocessandghrelinlevelsmaychangemorerapidthanweightloss,theincreaseinghrelininthosechronicdiseasesisunlikelyresultfromtheinsufficienttorecovertothepreviousbodyweight.Moreover,thisauthoralsoreportedthatfollow-upplasmaghrelinlevelincreasedinthepresenceofanorexiaafterchemotherapy,whichfurthersuggeststhattheincreaseghrelinlevelmayrepresentacompensatorymechanismundercatabolic–anabolicimbalanceincachecticpatientswithlungcancer1.
3.TheauthorsshouldrefertotheoriginalreportthatIL-1bdecreaseplasmaghrelinlevels(Gastroentelorogy120:
337-345,2001)
Wereferredthisarticleasthereviewersuggested.Infact,thisisamistakeofus.Manythanksforthereviewer’ssuggestion.
4.Ref.13dosenotincludedataonghrelin.
WearesosorrytomakethismistakeforcitingtheRef.13.Wereplacedthereferenceinthepaper.
5.Thereisnoreportthatdesacylghrelinstimulatesfoodintake.Itistheconsensusatpresentacylghrelinisinvolvedinfeedingresponsetostarvation.Therefore,theauthorsshouldbecarefulabouttheirinterpretationdescribedinthelastparagraphinpage10.
Wemadeitclearinthepaperthatghrelinhastwoisoforms(“active”and“inactive”).Onlythe“active”isoformisinvolvedinfeedingresponsetostarvation.Butthe“inactive”isoformhasotheractivitieslikeanti-proliferativeactivityontumorcelllinesasdescribedinthemanuscript.
Toreviewer #2
Majorcomments
1.EarlierstudieshaveshownthatcirculatingghrelinlevelisincreasedinunderweightpatientswithCHF,lungcancer,andlivercirrhosis.Inthepresentstudy,however,plasmaghrelinlevelwasdecreaseddespiteasignificantweightlossinCOPD.Inaddition,earlierstudieshavereportedthatcirculatingghrelincorrelatedpositivelywithBMIinpatientswithCHFandlungcancer.However,thepresentstudydemonstratedthatplasmaghrelinlevelcorrelatedpositivelywithBMIinCOPDpatients.Thus,thereareconsiderablediscrepanciesbetweenthepresentstudyandearlierstudies.Thesediscrepanciesshouldbediscussedindetail.TheauthoralsostatedtheregulationofghrelinsecretionwasdisturbedinCOPDpatients.However,theydidnotclarifythismechanism.
WestatedthattheroleofghrelininpatientswithCOPDmaybedifferentfromitsroleinCHF,cancerandlivercirrhosisanddiscussedthisdifferenceinthelastparagraphofpage9.
Followingthereviewer’ssuggestion,weaddedthat“plasmaghrelincorrelatedpositivelywithpercentpredictedresidualvolumeandresidualvolume/totallungcapacityratio”astheevidenceforfurthersupportingthatrespiratoryabnormalitiesmaytakepartintheregulationofplasmaghrelinlevels.
2.TheauthorsdemonstratedthatplasmaghrelinlevelcorrelatednegativelywithplasmaTND-aandCRPinCOPDpatients.However,Nagayaetal.haveshownthatplasmaghrelinlevelcorrelatespositivelywithplasmaTNF-alevelinpatientswithCHF.Thisdiscrepancyshouldbediscussed.
Accordingtothereviewerindicated,wediscussedthisdiscrepancyinthesecondparagraphofpage9.
3.TheauthorstatedthatrespiratoryabnormalitiesmaytakepartintheregulationofplasmaghrelinlevelinCOPD.TheauthorsshoulddescribletherelationshipbetweenplasmaghrelinlevelandpulmonaryfunctioninCOPD.
Thereareevidencesthatrespiratoryabnormalitiesmaytakepartintheregulationofplasmaghrelinlevelinlungdiseaseswithrespiratoryabnormalities2,3.AsourstudywasdesignedtoinvestigatewhethertheplasmaghrelinlevelsareincreasedordecreasedinCOPDandwhethertheplasmaghrelinlevelsrelatestotheincreasedsystemicinflammationinthosepatients,sowedidn’tanalysistherelationshipbetweenplasmaghrelinlevelandpulmonaryfunction.
Minorcomments
1.Circulatingghrelinlevelexhibitsacircadianrhythm.Therefore,theauthorsshoulddescriblethelimitationoftheirmeasurementofghrelininsinglesamples.
It’struethatcirculatingghrelinlevelexhibitsacircadianrhythmandtomonitortheghrelinlevelsindifferenttimepointsisbetterthanjustmeasuredasinglesample.However,wecollectedthesamplesatthefastingstate(from9:
00p.m.onthepreviousnight.)byvenipunctureat7:
00a.m.asmoststudiesdid2,4.Soourresultscanexcludethepossibilitythatthedifferencebetweengroupswasresultfromthecircadianrhythmofghrelinandarewellcomparedwithotherstudies.
2.IntheResultssection,plasmaghrelinlevelinhealthycontrolswasdifferentwiththatin0.25+0.22ng/ml,whereas,inFigure1A,itwasapproximately1.8ng/ml.
Wefixedthisinourrevisedmanuscript.Wearesosorrytomakethismistake.
Toreviewer #3
1.AboutthepaperofItohetalinAJRCC.
Asthereviewersaid,thestudybyItohetalwasnotpublishedwhenthecurrentmanuscriptweresubmitted.Wediscussedthedifferencebetweenthefindingsoftheirstudyandourstudyinrevisedmanuscript.
2.Abstract
Conclusion:
“plasmaghrelindecreasedinCOPD”.ThissoundsliketheauthorshavefollowedsubjectsforalongtimeandthatthediagnosisCOPDwasconformed,theplasmaghrelindecreased.Thiswashowevernottheaimnorthecase-areformulationisnecessary.
Wefixedthisasthereviewersuggestedinourrevisedmanuscript.
3.Introduction
(1)Page2.Ref.1.isalettertotheeditorinBrJNutrandisacommentconceringanearlierpublishedpaper.Itisnotareferencethatsupportthestatement.Severalotherreferencesexistintheliteraturetobeusedinstead.
Thanksforthereviewer’ssuggestion.Wereplacedthisreferencebyotherone.
(2)Page2,line5.“Tounderstandweightlossmechanismsinthisdiseasemaybehelpfultoimprovequalityoflifeinthesepatients”.Doyoureallythinkthatifweresearchersunderstandthemechanismsthatautomaticallywouldmakethepatientshappier?
Wereplacedthissentencewith“Tounderstandweightlossmechanismsinthisdiseasemaybehelpfultocombatweightlossinthesepatients”
4.Methods
(1)Patients:
Howwerethepatientandcontrolsubjectsselected?
Theauthorsstatethatnoneofthecontrolsubjectswastakingandmedications-wasthatalsothecaseforthepatients?
Thatwasalsothecaseforthepatients.Infact,mostoftheCOPDpatientsinChinadonottakeanymedicationswhenthediseaseisclinicallystablebecauseofeconomicreason.
Page4,line2.AshortdescriptionofATScriteriawouldbehelpfulforreaderswhoarenotfamiliarwiththosecriteria.
Asthosecriteriaarewidelyusedbyresearcherandphysicians,wedidnotdescribetheminourpaperassomepaperdid.Ifyouthinkitisnecessarytodoso,wemayaddashortdescription.
Page4,line3,whatdoyoumeanby“otherdiseases”?
COPDpatientsmostoftenhavealotofotherdiseases.
Wearesosorrytomis-expressthis-wejustmeansthatthosepatientsdidnothavethediseasethatknowntoaffecttheplasmaghrelinlevel.Wefixeditinourrevisedmanuscript.
Page4,line5.IfIunderstanditcorrectly,noneoftheCOPDpatientsweresmokersorex-smokers,i.e.anotherreasonexistsfortheirCOPD.CigarettesmokingisthemaincauseofCOPD,buthereyouhavestudiedpatientshavingotherreasonsforthedisease.Whatdosethismeanregardingtherepresentativityofthestudygroup?
Coulditaffecttheresultsinsomeway?
Smokingincreasestheplasmaghrelinlevel5.Itisdifficultforustodefine“ex-smokers”becausethereisnostudyaboutthatwhethertheex-smokingwillaffecttheplasmaghrelinlevelornot.Thismayleadtotherepresentativityproblem.However,thosepatientsinourstudystilllosttheweightandhadsysteminflammationasmostCOPDpatientsdid.Furtherstudyshouldbedesignedtoinvestigatetheeffectofex-smokingonplasmaghrelinlevel.
Page4,line6.WhydotheauthorsrefertoWhatmoreetal?
Thatstudyinvestigatedghrelininhealthyadolescentsandhasnothingtodowithfactorknowntoaffectserumghrelinlevel.
Wearesorrytomakethismistake.Wereplacedthisreference.
(2)Bodycomposition
Page4,lastline–page5,line1.ThedeuteriumdilutionstudyperformedbyBaarendsetalwasusingarm–to–footbioelectricalimpedancespectroscopy.Inthecurrentmanuscriptthefoot–to–footbioelectricalimpedanceassessmentisused.Thereadersa
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