孕期过多补充维生素D导致宝宝食物过敏Word格式.docx
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孕期过多补充维生素D导致宝宝食物过敏Word格式.docx
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e博士的团队进行试验的样本来自于LiNA群体队列,这是一个由莱比锡Helmholtz环境研究中心与St.Georg市政诊所共同收集的2006-2008年的队列数据。
“生活方式以及环境因素对新生儿过敏风险的影响”的长期研究中,总计使用了622位母亲以及她们的629个孩子的数据。
研究人员对孕妇血液维生素D的含量以及婴儿脐带血维生素D的含量都进行了测量,此外,研究人员还对这些孩子2岁之内发生的食物过敏情况进行了调查评估。
结果显示,那些血液中维生素D含量较低的孕妇,她们的孩子在2岁内发生食物过敏的情况明显要少很多。
反过来,这也说明孕妇血液中维生素D含量过高与孩子食物过敏发生率的升高有关联。
而且,研究人员同时发现由于容易对蛋白、牛奶、面粉、花生以及黄豆等食物过敏,那些孩子体内免疫球蛋白E的含量也会升高。
此外,莱比锡Helmholtz环境研究中心科学家还发现了维生素D与食物过敏之间的机理。
来自莱比锡Helmholtz环境研究中心环境免疫部门的GundaHerberth博士还深入观察了儿童的过敏反应,并分析了脐带血中的调节性T细胞。
这种细胞可以防止过敏反应的发生。
莱比锡Helmholtz环境研究中心的研究人员从之前的分析中得知,那些脐带血中调节性T细胞不足的孩子更容易出现过敏。
有趣的是,血液中维生素D含量越高,体内调节性T细胞越少,这种关系意味着维生素D会抑制调节性T细胞的生成,最终导致过敏的出现。
除了饮食以外,体内维生素D含量还会受到其它因素的影响,例如季节、日照时间等。
这些因素也应该被纳入到维生素D与食物过敏的风险分析中。
莱比锡Helmholtz环境研究中心的研究人员建议孕妇尽量少服用维生素D营养品,他们说:
“基于我们的研究,体内维生素D含量过高确实会增加孩子在2岁前发生过敏情况的几率。
”
Fishintakeduringpregnancyandtheriskofchildasthmaandallergicrhinitis–longitudinalevidencefromtheDanishNationalBirthCohort
EkaterinaMaslova,MarinStrø
m,EmilyOken,HanniaCampos,ChristophLange,DianeGoldandSjurdurF.Olsen
BritishJournalofNutrition,2013,1
BritishJournalofNutrition/FirstViewArticlepp1-13
Copyright©
TheAuthors2013
DOI:
http:
//dx.doi.org/10.1017/S0*******1300038X(AboutDOI),Publishedonline:
08March2013
Abstract
Maternalfishintakeduringpregnancymayinfluencetheriskofchildasthmaandallergicrhinitis,yetevidenceisconflictingonitsassociationwiththeseoutcomes.Weexaminedtheassociationsofmaternalfishintakeduringpregnancywithchildasthmaandallergicrhinitis.MothersintheDanishNationalBirthCohort(n28936)reportedtheirfishintakeat12and30weeksofgestation.Usingmultivariatelogisticregression,weexaminedtheassociationsoffishintakewithchildwheeze,asthmaandrhinitisassessedatseveraltimepoints:
everwheeze,recurrentwheeze(>
3episodes),everasthmaandallergicrhinitis,andcurrentasthma,assessedat18months(napproximately22000)and7years(napproximately17000)usingself-reportandregistrydataonhospitalisationsandprescribedmedications.Comparedwithconsistentlyhighfishintakeduringpregnancy(fishasasandwichorhotmeal≥2–3times/week),nevereatingfishwasassociatedwithahigherriskofchildasthmadiagnosisat18months(OR1·
30,95%CI1·
05,1·
63,P=0·
02),andeverasthmabyhospitalisation(OR1·
46,95%CI0·
99,2·
13,P=0·
05)andmedicationprescription(OR1·
37,95%CI1·
10,1·
71,P=0·
01).Adose–responsewaspresentforasthmaat18monthsonly(Pfortrend=0·
001).Wefoundnoassociationswithwheezeorrecurrentwheezeat18monthsorwithallergicrhinitis.Theresultssuggestthathigh(v.no)maternalfishintakeduringpregnancyisprotectiveagainstbothearlyandeverasthmain7-year-oldchildren.
母亲孕期
(ReceivedJuly252012)
(RevisedJanuary152013)
(AcceptedJanuary212013)
Maternalfishconsumptionduringpregnancyandrisksofwheezingandeczemainchildhood:
TheGenerationRStudy
ETMLeermakers,AMMSonnenschein-vanderVoort,DHMHeppe,JCdeJongste,HAMoll,OHFranco,AHofman,VWVJaddoeandLDuijts
EuropeanJournalofClinicalNutrition67,353-359(April2013)|doi:
10.1038/ejcn.2013.36
Background/Objectives:
Maternalfishconsumptionduringpregnancymightinfluencethefetalimmunesystemthroughanti-inflammatoryeffectsofomega-3fattyacids,andmightaffecttherisksofchildhoodasthmaandatopy.InGenerationR,aprospectivecohortstudyintheNetherlands,weexaminedtheassociationsoffirsttrimesterfishconsumptionwithchildhoodwheezingandeczemainthefirst4yearsoflife.
Methods:
Intotal,2976motherscompleteda293-itemsemiquantitativefoodfrequencyquestionnairecoveringdietaryintakeinthefirsttrimester.Theoccurrenceofwheezingandeczemawasyearlyassessedbyquestionnaires.
Results:
Medianweeklyfishconsumptionwas83(95%range0–316)gramsperweek.Weobservednoconsistentassociationsofmaternaltotal-,lean-orfatty-fishconsumptionduringpregnancywiththerisksofchildhoodwheezing.Maternalshellfishconsumptionof1–13 gperweekwasassociatedwithoverallincreasedrisksofchildhoodwheezingandeczema(OR1.20(1.04,1.40)andOR1.18(1.01,1.37),respectively).Maternalfattyfishconsumptionof35–69 gperweekwasassociatedwithincreasedoverallrisksofchildhoodeczema(OR1.17(1.00,1.38)),butmaternaltotal-orlean-fishconsumptionwasnot.
Conclusions:
Duringpregnancy,shellfishconsumptionwasassociatedwithincreasedrisksofwheezingandeczema,whilefattyfishconsumptionwasassociatedwithahigherriskofeczemaonly.Maternaltotalfishorleanfishconsumptionwerenotassociatedwithwheezingoreczema.Furtherstudiesareneededtoreplicatethesefindingsandtoexploreunderlyingmechanisms.
Mediterraneandietadherenceduringpregnancyandriskofwheezeandeczemainthefirstyearoflife:
INMA(Spain)andRHEA(Greece)mother–childcohortstudies
LedaChatzi,RaquelGarcia,TheanoRoumeliotaki,MikelBasterrechea,HaizeaBegiristain,CarmenIñ
iguez,JesusVioque,ManolisKogevinasandJordiSunyeronbehalfoftheINMAandRHEAstudygroups
BritishJournalofNutrition/FirstViewArticlepp1-11BritishJournalofNutrition,2013,1
TheAuthors2013
//dx.doi.org/10.1017/S0*******13001426(AboutDOI),Publishedonline:
17May2013
Maternaldietduringpregnancymightinfluencethedevelopmentofchildhoodallergicdisorders.TheaimofthepresentstudywastoevaluatetheimpactofMediterraneandiet(MD)adherenceduringpregnancyonwheezeandeczemainthefirstyearoflifeintwopopulation-basedmother–childcohortsinSpainandGreece.Westudied1771mother–newbornpairsfromtheSpanishmulti-centre‘INMA’(INfanciayMedioAmbiente)study(Gipuzkoa,SabadellandValencia)and745pairsfromthe‘RHEA’studyinCrete,Greece.ThesymptomsofwheezeandeczemawerebasedonthecriteriaoftheInternationalStudyofAsthmaandAllergiesinChildhood.MaternaldietduringpregnancywasassessedbyFFQandMDadherencewasevaluatedthroughanaprioriscore.Multivariatelog-binomialregressionmodelswereusedtoadjustforseveralconfoundersineachcohortandsummaryestimateswereobtainedbyameta-analysis.MDadherencewasnotassociatedwiththeriskofwheezeandeczemainanycohort,andsimilarresultswereidentifiedinthemeta-analysisapproach.Highmeatintake(relativerisk(RR)1·
22,95%CI1·
00,1·
49)and‘processed’meatintake(RR1·
18,95%CI1·
02,1·
37)duringpregnancywereassociatedwithanincreasedriskofwheezeinthefirstyearoflife,whileahighintakeofdairyproductswassignificantlyassociatedwithadecreasedriskofinfantilewheeze(RR0·
83,95%CI0·
72,0·
96).Theresultsofthepresentstudyshowthathighmeatintakeduringpregnancymayincreasetheriskofwheezeinthefirstyearoflife,whileahighintakeofdairyproductsmaydecreaseit.
Maternalintakeoffattyacidsduringpregnancyandallergiesintheoffspring
BrightI.Nwaru,MaijaliisaErkkola,MirkaLumia,CarinaKronberg-Kippilä
SuviAhonen,MinnaKaila,JormaIlonen,OlliSimell,MikaelKnip,RiittaVeijolaandSuviM.Virtanen
BritishJournalofNutrition
BritishJournalofNutrition/Volume108/Issue04/August2012,pp720-732
TheAuthors2011
//dx.doi.org/10.1017/S0*******11005940(AboutDOI),Publishedonline:
09November2011
Fattyacids(FA)areknowntohaveanumberofimmunologicaleffectsand,accordingly,mayplayaroleinthedevelopmentofallergicdiseases.WeinvestigatedtheeffectofmaternalintakeofFAduringpregnancyontheriskofallergicrhinitis,wheezeandatopiceczemainchildrenaged5years.ThepresentstudyanalyseddatafromtheFinnishType1DiabetesPredictionandPreventionNutritionStudy,apopulation-basedbirthcohortstudywitha5-yearfollow-up.Completeinformationonmaternaldiet(assessedbyavalidatedFFQ)andInternationalStudyofAsthmaandAllergiesinChildhood-basedallergicoutcomeswasavailablefor2441children.Coxproportionalregressionandlogisticregressionwereusedfortheanalyses.Afteradjustingforpotentialconfoundingvariables,highmaternalconsumptionofbutterandbutterspreads(hazardratio(HR)1·
33;
95%CI1·
03,1·
71)andhigherratioofn-6:
n-3FA(HR1·
37;
07,1·
77)duringpregnancywereassociatedwithanincreasedriskofallergicrhinitisintheoffspringby5yearsofage.HighmaternalintakesoftotalPUFA(HR0·
71;
95%CI0·
52,0·
96)andα-linolenicFA(HR0·
73;
54,0·
98)wereassociatedwithadecreasedriskofallergicrhinitis.However,theseresultslosttheirsignificanceafteradjustmentformultiplecomparisons.Overall,ourdatasuggestthatmaternalconsumptionofbutter,theratioofn-6:
n-3FAandintakeofPUFAandα-linolenicFAduringpregnancymaybepotentialdeterminantsofallergicrhinitisintheoffspring.
FishandfatintakeandprevalenceofallergicrhinitisinJapanesefemales:
theOsakaMaternalandChildHealthStudy
MiyakeY,SasakiS,TanakaK,OhyaY,MiyamotoS,MatsunagaI,YoshidaT,HirotaY,OdaH
JAmCollNutr.2007Jun;
26(3):
279-87.
OBJECTIVE:
Itremainsuncertainwhetherintakeoffishorn-3polyunsaturated
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- 关 键 词:
- 孕期 过多 补充 维生素 导致 宝宝 食物 过敏
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