生物信息学英文术语及释义总汇.doc
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生物信息学英文术语及释义总汇.doc
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AbstractSyntaxNotation(ASN.l)(NCBI发展的许多程序,如显示蛋白质三维结构的Cn3D等所使用的内部格式)
Alanguagethatisusedtodescribestructureddatatypesformally,Withinbioinformatits,ithasbeenusedbytheNationalCenterforBiotechnologyInformationtoencodesequences,maps,taxonomicinformation,molecularstructures,andbiographicalinformationinsuchawaythatitcanbeeasilyaccessedandexchangedbycomputersoftware.
Accessionnumber(记录号)
AuniqueidentifierthatisassignedtoasingledatabaseentryforaDNAorproteinsequence.
Affinegappenalty(一种设置空位罚分策略)
Agappenaltyscorethatisalinearfunctionofgaplength,consistingofagapopeningpenaltyandagapextensionpenaltymultipliedbythelengthofthegap.Usingthispenaltyschemegreatlyenhancestheperformanceofdynamicprogrammingmethodsforsequencealignment.SeealsoGappenalty.
Algorithm(算法)
Asystematicprocedureforsolvingaprobleminafinitenumberofsteps,typicallyinvolvingarepetitionofoperations.Oncespecified,analgorithmcanbewritteninacomputerlanguageandrunasaprogram.
Alignment(联配/比对/联配)
Referstotheprocedureofcomparingtwoormoresequencesbylookingforaseriesofindividualcharactersorcharacterpatternsthatareinthesameorderinthesequences.Ofthetwotypesofalignment,localandglobal,alocalalignmentisgenerallythemostuseful.SeealsoLocalandGlobalalignments.
Alignmentscore(联配/比对/联配值)
Analgorithmicallycomputedscorebasedonthenumberofmatches,substitutions,insertions,anddeletions(gaps)withinanalignment.ScoresformatchesandsubstitutionsArederivedfromascoringmatrixsuchastheBLOSUMandPAMmatricesforproteins,andaftinegappenaltiessuitableforthematrixarechosen.Alignmentscoresareinlogoddsunits,oftenbitunits(logtothebase2).Higherscoresdenotebetteralignments.SeealsoSimilarityscore,Distanceinsequenceanalysis.
Alphabet(字母表)
Thetotalnumberofsymbolsinasequence-4forDNAsequencesand20forproteinsequences.
Annotation(注释)
Thepredictionofgenesinagenome,includingthelocationofprotein-encodinggenes,thesequenceoftheencodedproteins,anysignificantmatchestootherProteinsofknownfunction,andthelocationofRNA-encodinggenes.Predictionsarebasedongenemodels;e.g.,hiddenMarkovmodelsofintronsandexonsinproteinsencodinggenes,andmodelsofsecondarystructureinRNA.
AnonymousFTP(匿名FTP)
WhenaFTPserviceallowsanyonetologin,itissaidtoprovideanonymousFTPser-vice.AusercanlogintoananonymousFTPserverbytypinganonymousastheusernameandhisE-mailaddressasapassword.MostWebbrowsersnownegotiateanonymousFTPlogonwithoutaskingtheuserforausernameandpassword.SeealsoFTP.
ASCII
TheAmericanStandardCodeforInformationInterchange(ASCII)encodesunaccentedlettersa-z,A-Z,thenumbersO-9,mostpunctuationmarks,space,andasetofcontrolcharacterssuchascarriagereturnandtab.ASCIIspecifies128charactersthataremappedtothevaluesO-127.ASCIItilesarecommonlycalledplaintext,meaningthattheyonlyencodetextwithoutextramarkup.
BACclone(细菌人工染色体克隆)
BacterialartificialchromosomevectorcarryingagenomicDNAinsert,typically100–200kb.Mostofthelarge-insertclonessequencedintheprojectwereBACclones.
Back-propagation(反向传输)
Whentrainingfeed-forwardneuralnetworks,aback-propagationalgorithmcanbeusedtomodifythenetworkweights.Aftereachtraininginputpatternisfedthroughthenetwork,thenetwork’soutputiscomparedwiththedesiredoutputandtheamountoferroriscalculated.Thiserrorisback-propagatedthroughthenetworkbyusinganerrorfunctiontocorrectthenetworkweights.SeealsoFeed-forwardneuralnetwork.
Baum-Welchalgorithm(Baum-Welch算法)
AnexpectationmaximizationalgorithmthatisusedtotrainhiddenMarkovmodels.
Baye’srule(贝叶斯法则)
Formsthebasisofconditionalprobabilitybycalculatingthelikelihoodofaneventoccurringbasedonthehistoryoftheeventandrelevantbackgroundinformation.IntermsoftwoparametersAandB,thetheoremisstatedinanequation:
Thecondition-alprobabilityofA,givenB,P(AIB),isequaltotheprobabilityofA,P(A),timestheconditionalprobabilityofB,givenA,P(BIA),dividedbytheprobabilityofB,P(B).P(A)isthehistoricalorpriordistributionvalueofA,P(BIA)isanewpredictionforBforaparticularvalueofA,andP(B)isthesumofthenewlypredictedvaluesforB.P(AIB)isaposteriorprobability,representinganewpredictionforAgiventhepriorknowledgeofAandthenewlydiscoveredrelationshipsbetweenAandB.
Bayesiananalysis(贝叶斯分析)
Astatisticalprocedureusedtoestimateparametersofanunderlyingdistributionbasedonanobserveddistribution.SeealsoBaye’srule.
Biochips(生物芯片)
Miniaturizedarraysoflargenumbersofmolecularsubst
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- 生物 信息学 英文 术语 释义 总汇
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