实验四.docx
- 文档编号:17425509
- 上传时间:2023-04-24
- 格式:DOCX
- 页数:33
- 大小:28.52KB
实验四.docx
《实验四.docx》由会员分享,可在线阅读,更多相关《实验四.docx(33页珍藏版)》请在冰豆网上搜索。
实验四
核酸序列NM_000230Fasta格式
>gi|169790920|ref|NM_000230.2|Homosapiensleptin(LEP),mRNA
GTAGGAATCGCAGCGCCAGCGGTTGCAAGGCCCAAGAAGCCCATCCTGGGAAGGAAAATGCATTGGGGAA
CCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAAGCTGTGCCCATCCAAAAAGTCCA
AGATGACACCAAAACCCTCATCAAGACAATTGTCACCAGGATCAATGACATTTCACACACGCAGTCAGTC
TCCTCCAAACAGAAAGTCACCGGTTTGGACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGA
TGGACCAGACACTGGCAGTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATC
CAACGACCTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCCTGG
GCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTACTCCACAGAGGTGG
TGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAGCTGGACCTCAGCCCTGGGTGCTG
AGGCCTTGAAGGTCACTCTTCCTGCAAGGACTACGTTAAGGGAAGGAACTCTGGCTTCCAGGTATCTCCA
GGATTGAAGAGCATTGCATGGACACCCCTTATCCAGGACTCTGTCAATTTCCCTGACTCCTCTAAGCCAC
TCTTCCAAAGGCATAAGACCCTAAGCCTCCTTTTGCTTGAAACCAAAGATATATACACAGGATCCTATTC
TCACCAGGAAGGGGGTCCACCCAGCAAAGAGTGGGCTGCATCTGGGATTCCCACCAAGGTCTTCAGCCAT
CAACAAGAGTTGTCTTGTCCCCTCTTGACCCATCTCCCCCTCACTGAATGCCTCAATGTGACCAGGGGTG
ATTTCAGAGAGGGCAGAGGGGTAGGCAGAGCCTTTGGATGACCAGAACAAGGTTCCCTCTGAGAATTCCA
AGGAGTTCCATGAAGACCACATCCACACACGCAGGAACTCCCAGCAACACAAGCTGGAAGCACATGTTTA
TTTATTCTGCATTTTATTCTGGATGGATTTGAAGCAAAGCACCAGCTTCTCCAGGCTCTTTGGGGTCAGC
CAGGGCCAGGGGTCTCCCTGGAGTGCAGTTTCCAATCCCATAGATGGGTCTGGCTGAGCTGAACCCATTT
TGAGTGACTCGAGGGTTGGGTTCATCTGAGCAAGAGCTGGCAAAGGTGGCTCTCCAGTTAGTTCTCTCGT
AACTGGTTTCATTTCTACTGTGACTGATGTTACATCACAGTGTTTGCAATGGTGTTGCCCTGAGTGGATC
TCCAAGGACCAGGTTATTTTAAAAAGATTTGTTTTGTCAAGTGTCATATGTAGGTGTCTGCACCCAGGGG
TGGGGAATGTTTGGGCAGAAGGGAGAAGGATCTAGAATGTGTTTTCTGAATAACATTTGTGTGGTGGGTT
CTTTGGAAGGAGTGAGATCATTTTCTTATCTTCTGCAATTGCTTAGGATGTTTTTCATGAAAATAGCTCT
TTCAGGGGGGTTGTGAGGCCTGGCCAGGCACCCCCTGGAGAGAAGTTTCTGGCCCTGGCTGACCCCAAAG
AGCCTGGAGAAGCTGATGCTTTGCTTCAAATCCATCCAGAATAAAACGCAAAGGGCTGAAAGCCATTTGT
TGGGGCAGTGGTAAGCTCTGGCTTTCTCCGACTGCTAGGGAGTGGTCTTTCCTATCATGGAGTGACGGTC
CCACACTGGTGACTGCGATCTTCAGAGCAGGGGTCCTTGGTGTGACCCTCTGAATGGTCCAGGGTTGATC
ACACTCTGGGTTTATTACATGGCAGTGTTCCTATTTGGGGCTTGCATGCCAAATTGTAGTTCTTGTCTGA
TTGGCTCACCCAAGCAAGGCCAAAATTACCAAAAATCTTGGGGGGTTTTTACTCCAGTGGTGAAGAAAAC
TCCTTTAGCAGGTGGTCCTGAGACCTGACAAGCACTGCTAGGCGAGTGCCAGGACTCCCCAGGCCAGGCC
ACCAGGATGGCCCTTCCCACTGGAGGTCACATTCAGGAAGATGAAAGAGGAGGTTTGGGGTCTGCCACCA
TCCTGCTGCTGTGTTTTTGCTATCACACAGTGGGTGGTGGATCTGTCCAAGGAAACTTGAATCAAAGCAG
TTAACTTTAAGACTGAGCACCTGCTTCATGCTCAGCCCTGACTGGTGCTATAGGCTGGAGAAGCTCACCC
AATAAACATTAAGATTGAGGCCTGCCCTCAGGGATCTTGCATTCCCAGTGGTCAAACCGCACTCACCCAT
GTGCCAAGGTGGGGTATTTACCACAGCAGCTGAACAGCCAAATGCATGGTGCAGTTGACAGCAGGTGGGA
AATGGTATGAGCTGAGGGGGGCCGTGCCCAGGGGCCCACAGGGAACCCTGCTTGCACTTTGTAACATGTT
TACTTTTCAGGGCATCTTAGCTTCTATTATAGCCACATCCCTTTGAAACAAGATAACTGAGAATTTAAAA
ATAAGAAAATACATAAGACCATAACAGCCAACAGGTGGCAGGACCAGGACTATAGCCCAGGTCCTCTGAT
ACCCAGAGCATTACGTGAGCCAGGTAATGAGGGACTGGAACCAGGGAGACCGAGCGCTTTCTGGAAAAGA
GGAGTTTCGAGGTAGAGTTTGAAGGAGGTGAGGGATGTGAATTGCCTGCAGAGAGAAGCCTGTTTTGTTG
GAAGGTTTGGTGTGTGGAGATGCAGAGGTAAAAGTGTGAGCAGTGAGTTACAGCGAGAGGCAGAGAAAGA
AGAGACAGGAGGGCAAGGGCCATGCTGAAGGGACCTTGAAGGGTAAAGAAGTTTGATATTAAAGGAGTTA
AGAGTAGCAAGTTCTAGAGAAGAGGCTGGTGCTGTGGCCAGGGTGAGAGCTGCTCTGGAAAATGTGACCC
AGATCCTCACAACCACCTAATCAGGCTGAGGTGTCTTAAGCCTTTTGCTCACAAAACCTGGCACAATGGC
TAATTCCCAGAGTGTGAAACTTCCTAAGTATAAATGGTTGTCTGTTTTTGTAACTTAAAAAAAAAAAAAA
AAGTTTGGCCGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGGGGATCAC
AAGGTCACTAGATGGCGAGCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAACACAAAAGTTA
GCTGAGCGTGGTGGCGGGCGCCTGTAGTCCCAGCCACTCGGGAGGCTGAGACAGGAGAATCGCTTAAACC
TGGGAGGCGGAGAGTACAGTGAGCCAAGATCGCGCCACTGCACTCCGGCCTGATGACAGAGCGAGATTCC
GTCTTAAAAAAAAAAAAAAAAAAGTTTGTTTTTAAAAAAATCTAAATAAAATAACTTTGCCCCCTGCAAA
AAAAAAAAAAAAAA
核酸序列NM_000230的GenBank格式
LOCUSNM_0002303444bpmRNAlinearPRI25-MAY-2014
DEFINITIONHomosapiensleptin(LEP),mRNA.
ACCESSIONNM_000230
VERSIONNM_000230.2GI:
169790920
KEYWORDSRefSeq.
SOURCEHomosapiens(human)
ORGANISMHomosapiens
Eukaryota;Metazoa;Chordata;Craniata;Vertebrata;Euteleostomi;
Mammalia;Eutheria;Euarchontoglires;Primates;Haplorrhini;
Catarrhini;Hominidae;Homo.
REFERENCE1(bases1to3444)
AUTHORSLinkovF,BurkeLE,KomaroffM,EdwardsRP,LokshinA,StynMA,
TseytlinE,FreeseKEandBovbjergDH.
TITLEAnexploratoryinvestigationoflinksbetweenchangesinadipokines
andqualityoflifeinindividualsundergoingweightloss
interventions:
possibleimplicationsforcancerresearch
JOURNALGynecol.Oncol.133
(1),67-72(2014)
PUBMED24462731
REMARKGeneRIF:
Leptinwasassociatedwithphysicalqualityoflifein
overweight/obesewomenundergoingweightlossinterventions.
REFERENCE2(bases1to3444)
AUTHORSWoolleyJD,KhanBK,NatesanA,KarydasA,DallmanM,HavelP,
MillerBLandRankinKP.
TITLESatiety-relatedhormonaldysregulationinbehavioralvariant
frontotemporaldementia
JOURNALNeurology82(6),512-520(2014)
PUBMED24415571
REMARKGeneRIF:
Onlypatientswithbehavioralvariantfrontotemporal
dementiawhosignificantlyoverateinthelaboratorydemonstrated
significantlyhigherlevelsofleptincomparedwithcontrols.
REFERENCE3(bases1to3444)
AUTHORSHartCN,CarskadonMA,ConsidineRV,FavaJL,LawtonJ,RaynorHA,
JelalianE,OwensJandWingR.
TITLEChangesinchildren'ssleepdurationonfoodintake,weight,and
leptin
JOURNALPediatrics132(6),E1473-E1480(2013)
PUBMED24190680
REMARKGeneRIF:
Comparedwithdecreasedsleep,increasedsleepdurationin
school-agechildrenresultedinlowerreportedfoodintake,lower
fastingleptinlevels,andlowerweight.
REFERENCE4(bases1to3444)
AUTHORSKleinridders,A.,Lauritzen,H.P.,Ussar,S.,Christensen,J.H.,
Mori,M.A.,Bross,P.andKahn,C.R.
TITLELeptinregulationofHsp60impactshypothalamicinsulinsignaling
JOURNALJ.Clin.Invest.123(11),4667-4680(2013)
PUBMED24084737
REMARKGeneRIF:
Intype2diabetes,thereishypothalamicinsulin
resistanceandmitochondrialdysfunctionduetodownregulationof
themitochondrialchaperoneHSP60.HSP60reductionwasduetoa
lackofproperleptinsignaling.
REFERENCE5(bases1to3444)
AUTHORSCicchella,A.,Stefanelli,C.,Jurimae,T.,Saar,M.andPurge,P.
TITLEModeratephysicalactivitycorrelateswithelevatedleptinin
physicallyactive10-12-year-oldboyswithnormalBMI
JOURNALPerceptMotSkills117
(2),358-366(2013)
PUBMED24611241
REMARKGeneRIF:
Moderatephysicalactivitywascorrelatedwithleptin
levelsinphysicallyactive10-12yearoldboys.
REFERENCE6(bases1to3444)
AUTHORSIsseN,OgawaY,TamuraN,MasuzakiH,MoriK,OkazakiT,SatohN,
ShigemotoM,YoshimasaYandNishiS.
CONSRTMetal
TITLEStructuralorganizationandchromosomalassignmentofthehuman
obesegene
JOURNALJ.Biol.Chem.270(46),27728-27733(1995)
PUBMED7499240
REFERENCE7(bases1to3444)
AUTHORSMasuzakiH,OgawaY,IsseN,SatohN,OkazakiT,ShigemotoM,Mori
K,TamuraN,HosodaKandYoshimasaY.
CONSRTMetal
TITLEHumanobesegeneexpression.Adipocyte-specificexpressionand
regionaldifferencesintheadiposetissue
JOURNALDiabetes44(7),855-858(1995)
PUBMED7789654
REFERENCE8(bases1to3444)
AUTHORSZhangY,ProencaR,MaffeiM,BaroneM,LeopoldLandFriedmanJM.
TITLEPositionalcloningofthemouseobesegeneanditshumanhomologue
JOURNALNature372(6505),425-432(1994)
PUBMED7984236
REMARKErratum:
[Nature1995Mar30;374(6521):
479]
REFERENCE9(bases1to3444)
AUTHORSFriedmanJM,LeibelRL,SiegelDS,WalshJandBaharyN.
TITLEMolecularmappingofthemouseobmutation
JOURNALGenomics11(4),1054-1062(1991)
PUBMED1686014
REFERENCE10(bases1to3444)
AUTHORSGroot,P.H.,Scholte,H.R.andHulsmann,W.C.
TITLEFattyacidactivation:
specificity,localization,andfunction
JOURNALAdv.LipidRes.14,75-126(1976)
PUBMED3952
COMMENTREVIEWEDREFSEQ:
ThisrecordhasbeencuratedbyNCBIstaff.The
referencesequencewasderivedfromDA762132.1,U43653.1,
AC018635.10andBU752306.1.
ThissequenceisareferencestandardintheRefSeqGeneproject.
OnMar12,2008thissequenceversionreplacedgi:
4557714.
Summary:
Thisgeneencodesaproteinthatissecretedbywhite
adipocytes,andwhichplaysamajorroleintheregulationofbody
weight.Thisprotein,whichactsthroughtheleptinreceptor,
functionsaspartofasignalingpathwaythatcaninhibitfood
intakeand/orregulateenergyexpendituretomaintainconstancyof
theadiposemass.Thisproteinalsohasseveralendocrine
functions,andisinvolvedintheregulationofimmuneand
inflammatoryresponses,hematopoiesis,angiogenesisandwound
healing.Mutationsinthisgeneand/oritsregulatoryregionscause
severeobesity,andmorbidobesitywithhypogonadism.Thisgenehas
alsobeenlinkedtotype2diabetesmellitusdevelopment.[provided
byRefSeq,Jul2008].
SequenceNote:
ThisRefSeqrecordwascreatedfromtranscriptand
genomicsequencedatatomakethesequenceconsistentwiththe
referencegenomeassembly.Thegenomiccoordinatesusedforthe
transcriptrecordwerebasedontranscriptalignments.
PublicationNote:
ThisRefSeqrecordincludesasubsetofthe
publicationsthatareavailableforthisgene.PleaseseetheGene
recordtoaccessadditionalpublications.
##Evidence-Data-START##
Transcriptexoncombination:
:
U43653.1,BC060830.1[ECO:
0000332]
RNAseqintrons:
:
singlesamplesupportsallintrons
ERS025084,ERS025087[ECO:
0000348]
##Evidence-Data-END##
COMPLETENESS:
fulllength.
PRIMARYREFSEQ_SPANPRIMARY_IDENTIFIERPRIMARY_SPANCOMP
1-309DA762132.11-309
310-1807U43653.1309-1806
1808-3383AC018635.1034398-35973
3384-3444BU752306.11-61c
FEATURESLocation/Qualifiers
source1..3444
/organism="Homosapiens"
/mol_type="mRNA"
/db_xref="taxon:
9606"
/chromosome="7"
/map="7q31.3"
gene1..3444
/gene="LEP"
/gene_synonym="LEPD;OB;OBS"
- 配套讲稿:
如PPT文件的首页显示word图标,表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制:
部分文档作品中含有的国旗、国徽等图片,仅作为作品整体效果示例展示,禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词:
- 实验