胆囊的MRI成像Word文档下载推荐.docx
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胆囊的MRI成像Word文档下载推荐.docx
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5.PeterF.Hahn,MD,PhD,
6.JeffreyJ.Brown,MDand
7.RobertR.Edelman,MD
+AuthorAffiliations
1.1FromtheDepartmentofRadiology,DivisionofGastrointestinalRadiology,MassachusettsGeneralHospital,WHT270,55FruitSt,Boston,MA02114(O.A.C.,D.V.S.,S.P.K.,M.S.C.,P.F.H.);
MallinckrodtInstituteofRadiology,WashingtonUniversitySchoolofMedicine,StLouis,Mo(J.J.B.);
andtheDepartmentofRadiology,NorthwesternUniversitySchoolofMedicine,Evanston,Ill(R.R.E.).Presentedasaneducationexhibitatthe2004RSNAAnnualMeeting.ReceivedOctober23,2006;
revisionrequestedJanuary23,2007;
finalrevisionreceivedJune7;
acceptedJune11.Theauthorsdiscussaninvestigationalorunlabeleduseofacommercialproduct,device,orpharmaceuticalthathasnotbeenapprovedforsuchpurposebytheFDA.D.V.S.isaresearcherforGEHealthcareandaconsultantwithBraccoDiagnostics;
S.P.K.receivedresearchgrantsfromJohnson&
Johnson(Cordis)andCookandiswiththespeakers’bureauofJohnson&
Johnson;
J.J.B.isaconsultantwithTycoHealthcare(Mallinckrodt),BayerHealthcare,andGEHealthcareandiswiththespeakers’bureauofBraccoDiagnostics;
andR.R.E.receivedresearchsupportfromGEHealthcareandSchering(Berlex);
allremainingauthorshavenofinancialrelationshipstodisclose.
1.Addresscorrespondenceto
D.V.S.(e-mail:
dsahani@partners.org).
NextSection
Abstract
Thegallbladderservesastherepositoryforbileproducedintheliver.However,bilewithinthegallbladdermaybecomesupersaturatedwithcholesterol,leadingtocrystalprecipitationandsubsequentgallstoneformation.Themostcommondisordersofthegallbladderarerelatedtogallstonesandincludesymptomaticcholelithiasis,acuteandchroniccholecystitis,andcarcinomaofthegallbladder.Otherconditionsthatcanaffectthegallbladderincludebiliarydyskinesia(functional),adenomyomatosis(hyperplastic),andpostoperativechangesorcomplications(iatrogenic).Ultrasonography(US)hasbeenthetraditionalmodalityforevaluatinggallbladderdisease,primarilyowingtoitshighsensitivityandspecificityforbothstonediseaseandgallbladderinflammation.USperformedbeforeandafteringestionofafattymealmayalsobeusefulforfunctionalevaluationofthegallbladder.However,USislimitedbypatientbodyhabitus,withdegradationofimagequalityandanatomicdetailinobeseindividuals.Withtheadventoffasterandmoreefficientimagingtechniques,magneticresonance(MR)imaginghasassumedanincreasingroleasanadjunctmodalityforgallbladderimaging,primarilyinpatientswhoareincompletelyassessedwithUS.MRimagingallowssimultaneousanatomicandphysiologicassessmentofthegallbladderandbiliarytractinbothinitialevaluationofdiseaseandexaminationofthepostoperativepatient.ThisassessmentisaccomplishedchieflythroughtheuseofMRimagingcontrastagentsexcretedpreferentiallyviathebiliarysystem.
©
RSNA,2008
∙BOPTA=benzyloxypropionictetraacetate
∙CHD=commonhepaticduct
∙HIDA=hydroxyiminodiaceticacid
∙MnDPDP=mangafodipirtrisodium
∙SE=spin-echo
∙XGC=xanthogranulomatouscholecystitis
∙3D=three-dimensional
PreviousSectionNextSection
LEARNINGOBJECTIVESFORTEST3
Afterreadingthisarticleandtakingthetest,thereaderwillbeableto:
∙Discussthestate-of-the-artMRandMRcholangiographicimagingtechniquesforthediagnosisofgallbladderdisease.
∙DescribethenormalMRimagingfeaturesofthegallbladder.
∙IdentifytheMRimagingappearancesofgallbladderdisease.
Introduction
Thegallbladderisapear-shapedhollowviscuslocatedintherightupperquadrant,lodgedonthevisceralsurfaceoftheliverbetweensegmentsIVandV,andconnectedtothehepaticductthroughthecysticducttoformthecommonbileduct.Thegallbladderiscomposedofthefundus,whichusuallyprojectsbeyondtheinferiorborderoftheliver;
thebody;
andtheneck.Itisusually7–10cmlongand2.5cmwide,andthewallmeasureslessthan3mminthickness
(1).Thegallbladderservesastherepositoryforbileproducedintheliver,withanaveragevolumeof30–50mL
(2).Bilewithinthegallbladdermaybecomesupersaturatedwithcholesterol,leadingtocrystalprecipitationandsubsequentgallstoneformation.
Imagingofthegallbladderistypicallyrequestedforevaluationofrightupperquadrantpaininpatientswithorwithoutfeverandjaundice.Ultrasonography(US)istypicallytheinitialimagingmodality.However,technologicadvancesinmagneticresonance(MR)imagingsoftware,hardware,andcontrastmedia(eg,phased-arraysurfacecoils,breath-holdimaging,single-shotimagingtechniques,hepatobiliarycontrastagents)allowMRimagingtobeusedastheinitialimagingmodalityfortheevaluationofpain,jaundice,ormassesorasaproblem-solvingtoolforgallbladderdisease.Moreover,MRimagingallowsfunctionalassessmentofthegallbladderthroughtheuseofcontrastagentsexcretedpreferentiallyviathebiliarysystem.
Inthisarticle,wereviewMRimagingtechniquesfortheevaluationofthegallbladderandthenormalMRimagingappearanceofthisstructure.Inaddition,wediscussandillustratecongenitalabnormalitiesofthegallbladderandavarietyofpathologicconditionsaffectingthegallbladder(cholelithiasis,acuteandchroniccholecystitis,Mirizzisyndrome,xanthogranulomatouscholecystitis[XGC],adenomyomatosis,carcinoma,lymphoma,endometrialimplants).Wealsodiscussfunctionalevaluationofthegallbladderintheacutesetting,postoperativefunctionalevaluationofthegallbladderandbiliarytree,andtheassessmentofangiogenesisasapossiblefutureapplication.
ImagingTechniques
MRimagingsequencesshouldbetailoredtotheclinicalquestion.T2-weightedsequences(usuallyfastspin-echo[SE]sequenceswithrespiratorygating)areoptimalforevaluatingsoft-tissueabnormalitiesinvolvingthewallofthegallbladder,thebiliarysystem,andadjacentsoft-tissuestructures.Thesectionthicknessshouldbelessthan5mm,witha1–2-mmgapbetweensections.UsefuladditionalT2-weightedsequencesaresimilartothoseusedtoevaluatethebiliarytree(MRcholangiopancreatography)(Figs1,2):
acquisitiontechniquessuchashalf-Fourierrapidacquisitionwithrelaxationenhancementandsingle-shotfastSEimaging.AlthoughT1-weightedMRimagingofthegallbladdercanbeperformedwitheitherSEorbreath-holdspoiledgradient-echotechniques,thelatteraresuperiorbecausetheydecreaserespiratoryartifacts.
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Figure1a.
Two-dimensionalversusthree-dimensional(3D)MRcholangiopancreatography.(a)Duringtwo-dimensionalacquisition,athickslabisimagedinanobliqueplane.Two-dimensionalheavilyT2-weightedMRcholangiopancreatogramshowsfluid-filledstructures,whichmayoverlapbecausetheimagingisperformedinonlyoneplane.Thebiliaryandpancreaticductsarewellvisualized.(b)Three-dimensionalthin-sectionmaximum-intensity-projectionreformattedheavilyT2-weightedMRcholangiopancreatogramshowshowitispossibletorotateandseparatethestructureswitha3Dsequence.
Figure1b.
Figure2.
Three-dimensionalMRcholangiopancreatogramshowsthenormalgallbladder.Thecysticductappearsasacurvilinearbrightlineconnectingthegallbladderwiththecommonhepaticduct(CHD).Pancreasdivisumisincidentallynoted.
Dynamiccontrastmaterial–enhancedfat-suppressedT1-weightedMRimagingsequencesimprovethedelineationofthegallbladderwall,bileducts,andassociatedentitiessuchasinflammationandneoplasmsandallowassessmentoftheliverparenchymafortumorinvasionandmetastaticdisease(Table1).
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Table1.MRImagingProtocol
Twoagents,MnDPDPandgadoliniumBOPTA—thelatternotyethavingbeenapprovedintheUnitedStatesforevaluationofthegallbladderandbiliarytree—areexcretedintothebile.Afterbeinginjectedintravenously,theseagentsarespecificallytakenupbythehepatocytesandsubsequentlyexcretedintothebile,resultinginsignificantT1shorteningofthebile,whichappearshyperintenseonT1-weightedMRimages.Thisphenomenonpermitsevaluationofthephysiologiccharacteristicsofthegallbladderandbiliarytree.ThisbranchofMRcholangiographyisknownasfunctionalMRcholangiography(2–4).
NormalAppearanceoftheGallbladder
Thegallbladdershouldbeimagedafterthepatienthasfastedfor8–12hours,whichpromotesphysiologicdistentionofthegallbladder.OnT2-weightedimages,thegallbladderwallhaslowsignalintensityandstandsoutagainstthebrightvisceralfat.Th
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