大陆团来访学者演讲题目及摘要Word文档下载推荐.docx

大陆团来访学者演讲题目及摘要Word文档下载推荐.docx

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E-mail：

hao@

演講題目：

One-dimensionalhistogramsofrandomizedgenomicsequences---asurpriseanditsexplanation

摘要：

FromourjointworkdoneinTaiwanin1997-1998withH.C.Leeweknowthatthe1DhistogramsofK-stringsinprokaryotecompletegenomesaremuchbiasedtowardslowcountswithalongtailofhighcopy-numberrepeatsandtheirrandomizedcounterpartsshowabell-shapeddistributioncenteredaroundtheaveragecount.Tooursurprise,aninspectionofmoreavailablegenomesrevealsrichstructuresinanumberofrandomizedsequences,fromdiscretetooverlappingpeakswithKincreasing.Itturnsoutthatthisphenomenonismainlycausedbythesignificantdeviationofg+ccontentfromthatofa+t.Wehopethisstudymayeventuallyleadtoafinerwayofcharacterizingthenucleotidecontentofgenomicsequencesthanusingg+ccontentalone.ThistalkwillserveasanintroductiontothemoremathematicalexplanationbyH.M.Xiebyshowingmanycolorfulpictures.

歐陽鐘燦

中國科學院理論物理所研究員

E-mail：

oy@

TheelastictheoryofsinglemoleculeDNA

InthistalkwegiveasimplereviewontheexperimentsontheelasticdeformationofsinglemoelculeDNAandintroduceaelasticmodelwepresentedin1999toexplaintheexperimetal 

result

王鵬業

中國科學院理論物理研究所教授

pywang@

http：

//

Controlofspatiotemporaldynamicsinacardiacmodel

Atraveling-waveperturbationmethodtocontrolthespatiotemporaldynamicsinanexcitablecardiacmodelisproposed.Itisnumericallydemonstratedthatthemethodcansuccessfullysuppressthewaveinstability（alternansinactionpotentialduration）intheone-dimensionalcaseandconvertspiralwavesandturbulentstatestothenormaltravelingwavestatesinthetwo-dimensionalcase

史華林

中國科學院理論物理研究所副研究員

shihl@

CooperativeEffectsontheKineticsofATPHydrolysisinCollectiveMolecularMotors

Generally,molecularmotorsareATPase.Thereactionkineticsisstillanopenquestion.Inanrecentsinglemolecularexperimentperformedonkinesin（aprocessivemotor）,thekineticsofATPhydrolysishavebeenstudiedundercontrolledexternalloads.ItseemsthatthekineticsofATPhydrolysisstillcanbedescribedbytheMichaelis-Mentenmechanism,whichintroducedin1913todescribetheprocessofenzymaticcatalysis.ButtheMichaelisconstantisload-dependent.Thisexperimentalresulthasbeenexplainedwellwithatwo-stateratchetmodel.Wefocusoncollectivemolecularmotors.Withintheframeworkofatwo-stateratchetmodel,thecooperativeeffectsonthekineticsofATPhydrolysisforcollectivemolecularmotorshavebeenstudiedindetail.WecalculatethedependenceoftherateofATPconsumptionontheappliedloadasafunctionofATPconcentration.Newfeaturesdifferentfromsinglemolecularmotorhavebeendiscovered.Weanalysetwotypicaloscillationsofcollectivemolecularmotorsalongfilamentsindetail.Therelationbetweenoscillatorycharacteristics,suchasfrequencyandamplitude,aswellasthedutyratewithATPconcentrationhavebeendiscussed.

肖奕

華中科技大學物理系教授

yxiao@

Quasi-periodicityAnalysisofAluRepeats

ThegenomeofeukaryotesisknowntocontainvarioustypesofrepetitiveDNA.ThefunctionofrepetitiveDNAisunknown.AtypicalAluelementiscomposedoftwonearlyidenticalhalves（about130basepair）joinedbyamiddleA-richregionalongwitha3'

PolyA（Adenine）tail.SomeanalysisgaverisetotheconceptthatinterspersedrepetitivesequencesareselfishDNAwithnofunctionorselectiveadvantagetotheorganism[1],whileothersarguedagainstitandpresentedthattheinterspersedrepetitivesequencesarerelatedtoregulatorynetworks,allowingthecoordinateexpressionofmultiple,unlinkedgene[2].

WeanalyzeAluelementsbyusingquasi-periodicitymethodandthepurposeistofindoutwhetherthereexistsspecialcodingpatterninAluelement.ThesequencesofAluelementsusedcanbeobtainedinEMBLwebsite.ThetotalnumberoftheAluelementsare128.

Quasi-periodicitycanbeusedtofindthesizeofthewordofwhichasequenceconsists.Toshowthis,wecalculatedthequasi-periodicityofhumanexonsandweareimmediatelyimpressedbythesignificantpeakatquasi-period3whichisclearlyinducedbythattheexonsarewritteninthree-letterwords,i.e.,geneticcodes.

ToseeifAluelementsalsohavecertaincodingpattern,wecalculatedthequasi-periodicityof128Aluelements.Itissurprisedthatwedoseeasignificantpeakatquasi-period8.Amongthe128Aluelements,40sequenceshaveexactquasi-periodicityof8.Ifweaddthenumberofsequenceswithquasi-periodicityof7and9,thereare80sequenceswhichis80%ofthetotalsequences.

Thisresultagreeswithwha