雅思阅读模拟试题Word文件下载.doc
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雅思阅读模拟试题Word文件下载.doc
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cholesterolarestilloneofthemostpromisingmeanstocombatspirallingheartdisease.
2.DrugcompanyPfizerannouncedon2Decemberthatitwascancellingallclinicaltrialsoftorcetrapib,adrugdesignedtoraiseheart-protectivehigh-densitylipoproteins(HDLs)。
Inatrialof15000patients,asafetyboardfoundthatmorepeoplediedorsufferedcardiovascularproblemsaftertakingthedrugplusacholesterol-loweringstatinthanthoseinacontrolgroupwhotookthestatinalone.
3.Thenewscameasakickintheteethtomanycardiologistsbecauseearliertestsinanimalsandpeoplesuggesteditwouldlowerratesofcardiovasculardisease."
Therehavebeennoredflagstomyknowledge,"
saysJohnChapman,aspecialistinlipoproteinsandatherosclerosisattheNationalInstituteforHealthandMedicalResearch(INSERM)inPariswhohasalsostudiedtorcetrapib."
Thiscancellationcameasacompleteshock."
4.TorcetrapibisoneofthemostadvancedofanewbreedofdrugsdesignedtoraiselevelsofHDLs,whichferrycholesteroloutofartery-cloggingplaquestotheliverforremovalfromthebody.Specifically,torcetrapibblocksaproteincalledcholesterolestertransferprotein(CETP),whichnormallytransfersthecholesterolfromhigh-densitylipoproteinstolowdensity,plaque-promotingones.Statins,incontrast,mainlyworkbyloweringthe'
bad'
low-densitylipoproteins.
Underpressure
5.Researchersarenowtryingtoworkoutwhyandhowthedrugbackfired,somethingthatwillnotbecomeclearuntiltheclinicaldetailsarereleasedbyPfizer.Onehintliesinevidencefromearliertrialsthatitslightlyraisesbloodpressureinsomepatients.Itwasthoughtthatthismildproblemwouldbeoffsetbytheheartbenefitsofthedrug.Butitispossiblethatitactuallyprovedfatalinsomepatientswhoalreadysufferedhighbloodpressure.Ifbloodpressureistheexplanation,itwouldactuallybegoodnewsfordrugdevelopersbecauseitsuggeststhattheproblemsarespecifictothiscompound.OtherprototypedrugsthatarebeingdevelopedtoblockCETPworkinaslightlydifferentwayandmightnotsufferthesamedownfall.
6.ButitisalsopossiblethatthewholeideaofblockingCETPisflawed,saysMotiKashyap,whodirectsatherosclerosisresearchattheVAMedicalCenterinLongBeach,California.WhenHDLsexcretecholesterolintheliver,theyactuallyrelyonLDLsforpartofthisprocess.SoinhibitingCETP,whichpreventsthetransferofcholesterolfromHDLtoLDL,mightactuallycauseanabnormalandirreversibleaccumulationofcholesterolinthebody."
You'
reblockingaphysiologicmechanismtoeliminatecholesterolandeffectivelyconstipatingthepathway,"
saysKashyap.
Goingup
7.Mostresearchersremainconfidentthatelevatinghighdensitylipoproteinslevelsbyonemeansoranotherisoneofthebestroutesforhelpingheartdiseasepatients.ButHDLsarecomplexandnotentirelyunderstood.Oneapproveddrug,calledniacin,isknowntobothraiseHDLandreducecardiovascularriskbutalsocausesanunpleasantsensationofheatandtingling.Researchersareexploringwhethertheycanbypassthissideeffectandwhetherniacincanlowerdiseaseriskmorethanstatinsalone.Scientistsarealsoworkingonseveralothermeanstobumpuphigh-densitylipoproteinsby,forexample,introducingsyntheticHDLs."
Theonlythingweknowisdeadinthewateristorcetrapib,notthewholeideaofraisingHDL,"
saysMichaelMiller,directorofpreventivecardiologyattheUniversityofMarylandMedicalCenter,Baltimore.
(613wordsnature)
Thispassagehas7paragraphs1-7.
Choosethecorrectheadingforeachparagraphfromthelistofheadingsbelow.
Writethecorrectnumberi-ixinboxes1-7onyouranswersheet.
ListofHeadings
i.Howdoestorcetrapibwork?
ii.Contradictoryresultpriortothecurrenttrial
iii.Onefailuremaypossiblybringaboutfuturesuccess
iv.Thefailuredoesn‘tleadtototallossofconfidence
v.Itistherightroutetofollow
vi.Whyit‘sstopped
vii.Theymaycombineandtheoreticallyproduceidealresult
viii.What‘swrongwiththedrug
ix.Itmightbewrongatthefirstplace
Exampleanswer
Paragraph1iv
1.Paragraph2
2.Paragraph3
3.Paragraph4
4.Paragraph5
5.Paragraph6
6.Paragraph7
Questions7-13
Matchtorcetrapib,HDLs,statinandCETPwiththeirfunctions(Questions8-13)……
WritethecorrectletterA,B,CorDinboxes8-13onyouranswersheet.
NBYoumayuseanylettermorethanonce.
7.Ith
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