无针注射器数值模拟和工作特性分析外文文献翻译中英文翻译外文翻译.docx
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无针注射器数值模拟和工作特性分析外文文献翻译中英文翻译外文翻译.docx
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无针注射器数值模拟和工作特性分析外文文献翻译中英文翻译外文翻译
附录
Numericalsimulationofnon-needlesyringeandAnalysis
ZhengrongCuiandRussellJ.Mumper
Abstract:
TheCFDFluentsoftwarewithouttheworkofthesyringeneedletosimulatetheentireprocess,theliquidinjectionpipepressureandtheliquidjet-drivenchangesofspeed.Simulationoftheliquidjetintheairintheevolutionprocess,aswellasthejetpenetratestheskin,theskinlayerandsubcutaneouslayerofthewholeprocessofproliferation.Qualitativenumericalresultsandexperimentalresults.
Keywords:
non-needlesyringe;liquidjet;skin;puncture
1Introduction
Needle-freeinjectiondevicereferstotheuseofmechanicalhigh-pressuregeneratedbyinstantaneousaskedtopromotethePharmacy(liquidorfreeze-driedpowder)throughamicron-sizednozzlestoformahigh-speedjet,insteadofneedlestopenetratetheskinintothesubcutaneoustissue.Noneedleinjectionswithnopain,nocross-infection,theadvantagesofeaseofuse.
Needle-freeinjectiontechnologytoavoidacid,enzymedestructionofdrugabsorptionandstratumcorneumskinbarrierbreakthrough,nofirst-passeffect,withhigherbioavailability,appliedtolocalanesthetics,analgesics,cardiovasculardrugs,anti-tumor,anti-hepatitisdrug,suchasvarioustypesofdrugs,especiallyfortheacid,enzymeinstabilityofbiologicalmacromoleculesdrugsinjectiontoreplacetheordinarylocalorsystemicdrugdeliveryforawiderangeofdiseasepreventionandtreatment.Therapidabsorptionoftheordinaryinjection,highbioavailability,instabilityinthegastrointestinaltract,significantfirst-passeffectofthedrugisoftentheonlyoption,buttheinjectionmeansofdeliverywillinevitablyhavetoreducetissueinjuryinpatientswithcompliance,theuseoftheinconvenienceandthereistheriskofcrossinfection.Tothisend,alargenumberofresearchersinpharmaceuticalpreparationsintothewaysnon-injectiondrugdeliverysystemsofthestudy,anattempttoresolvetheinstabilityofdrugs,especiallybio-pharmaceuticsdrugsbottleneck.Syringewithoutneedle,suchasbyHingsondevelopedin1937,thefirsttimein1941forthevaccineandtheinjectionofinsulin.Sincethentheneedlefreesyringeresearchanddevelopmentandapplicationdevelopmentbyleapsandbounds.Needle-freeinjectionsolutiontopenetratetheskindepthdependsonthepinholediameterandthemainexportsofthetwoparametersofjetvelocity.Thesetwoparametersoftheexperimentalresearchandtheoreticalanalysis,aswellasnon-needlesyringeNumericalStudyofFluidDynamics'ontheperformanceofnon-needlesyringetoimproveandoptimizethedesignofgreatsignificance.Inthispaper,CFDFluentsoftwareworkonnon-needlesyringeforthewholeprocessofCFDsimulationandexperimentalresultsforthenewR&Dnon-needlesyringeAndprovideabasisforperformanceoptimization.
Needle-freepowderinjectionsystemsuitableforvarioustypesofdrugs,suchaslidocaine,influenzavaccines,AIDSvaccines,hepatitisBvaccine,insulin,suchasahugemarketshareofthedrughasenteredorwillenterintoclinicalresearch,inthenearfuturetothemarket,verysubstantialfutureeconomicprofits,inwhichtheneedle-freepowderlidocaineinjectionoftheexpectedsalesofuptosevenbillionU.S.dollars.Ontheotherhand,studieshaveshownthatmaybesingleorrepeateduseofpowder-freesyringeneedlecostsareexpectedtobesoldwiththeexistingpre-filledsyringe-typebalanced,willfurthercontributetothepromotionandpopularizationoftechnology,thedevelopmentofgoodpotentialandmarketprospects.
2Calculationofnon-needlesyringemodel
SyringewithoutneedlecavitygeometryasshowninFigure1.Syringewithoutneedleinjectionliquidvolumeisgenerally0.1~1.0ml,exportjetholediameterofabout100~200tLm,exportjetvelocityofabout100~200m/s.FlowReynoldsnumberof10~100,canberegardedaslaminarflow.Incompressiblefluidthecontinuityequation
(A-1)
Where,pisthedensityofliquid;tistime;vforthe勃勒operator;Vforthevelocityvector.
IncompressibleviscousfluidtheNavier-Stokesequation
(A-2)
Where,pispressure;vfortheflowviscositycoefficientofmovement;ffortheforceperunitvolume.
Style(A-1),type(A-2)isaviscousincompressiblefluidflowthebasicequations.Volumeforcewhichcannotbeconsidered.AsaresultofNavier-Stokesequationsandthenonlinearmodeloftheparticularityofthebasicanalyticalsolutioncannotbeobtained,numericalsimulationistostudynon-needleinjectionfluidanimportantmeansofdynamicprocesses.
3tosolvetheborderissueandtheprocessof
Syringeofliquidonthesurfaceattheentrancetotheinitialpressureimposedonhouseholdspn,jetexportstoatmosphericpressure,usingfinitevolumemethodcanbeobtainedinasyringeexportstnavera
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- 注射器 数值 模拟 工作 特性 分析 外文 文献 翻译 中英文
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